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| Thrombospondin type 1 domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Thrombospondin-1 | |||||||||
| Identifiers | |||||||||
| Symbol | TSP_1 | ||||||||
| Pfam | PF00090 | ||||||||
| InterPro | IPR000884 | ||||||||
| SMART | SM00209 | ||||||||
| PROSITE | PS50092 | ||||||||
| SCOP2 | 1lsl / SCOPe / SUPFAM | ||||||||
| |||||||||
Thrombospondins (TSPs) are a family of secreted glycoproteins with antiangiogenic functions. Due to their dynamic role within the extracellular matrix they are considered matricellular proteins.[1] The first member of the family, thrombospondin 1 (THBS1), was discovered in 1971 by Nancy L. Baenziger.[2]
- ^ Morris, Aaron H.; Kyriakides, Themis R. (July 2014). "Matricellular proteins and biomaterials". Matrix Biology. 37: 183–191. doi:10.1016/j.matbio.2014.03.002. PMC 4167162. PMID 24657843.
- ^ Baenziger NL, Brodie GN, Majerus PW (January 1971). "A Thrombin-Sensitive Protein of Human Platelet Membranes". Proc. Natl. Acad. Sci. U.S.A. 68 (1): 240–3. Bibcode:1971PNAS...68..240B. doi:10.1073/pnas.68.1.240. PMC 391203. PMID 5276296.
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