Thyrotropin-releasing hormone

thyrotropin-releasing hormone
Structural formula of TRH
Identifiers
Symbol	TRH
NCBI gene	7200
HGNC	12298
OMIM	275120
RefSeq	NM_007117
UniProt	P20396
Other data
Locus	Chr. 3 q13.3-q21
Search for Structures Swiss-model Domains InterPro

Thyrotropin-releasing hormone

Clinical data
ATC code	V04CJ02 (WHO)
Identifiers
CAS Number	24305-27-9
PubChem CID	638678
IUPHAR/BPS	2139
ChemSpider	554166
UNII	5Y5F15120W
KEGG	C03958
ChEBI	CHEBI:35940
ChEMBL	ChEMBL1472 Y
CompTox Dashboard (EPA)	DTXSID0023533
ECHA InfoCard	100.041.934
Chemical and physical data
Formula	C16H22N6O4
Molar mass	362.390 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1C[C@H](N(C1)C(=O)[C@H](CC2=CN=CN2)NC(=O)[C@@H]3CCC(=O)N3)C(=O)N
InChI InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1 Key:XNSAINXGIQZQOO-SRVKXCTJSA-N

Thyrotropin-releasing hormone (TRH) is a hypophysiotropic hormone produced by neurons in the hypothalamus that stimulates the release of thyroid-stimulating hormone (TSH) and prolactin from the anterior pituitary.

TRH has been used clinically for the treatment of spinocerebellar degeneration and disturbance of consciousness in humans.^[1] Its pharmaceutical form is called protirelin (INN) (/proʊˈtaɪrɪlɪn/).