Ticarcillin

Ticarcillin

Clinical data
AHFS/Drugs.com	Monograph
MedlinePlus	a685037
Pregnancy category	AU: B2
Routes of administration	Intravenous
ATC code	J01CA13 (WHO) J01CR03 (WHO)
Legal status
Legal status	In general: ℞ (Prescription only)
Pharmacokinetic data
Protein binding	45%
Elimination half-life	1.1 hours
Excretion	Renal
Identifiers
IUPAC name (2S,5R,6R)-6-{[(2R)-2-carboxy-2-(3-thienyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
CAS Number	34787-01-4 Y
PubChem CID	36921
DrugBank	DB01607 Y
ChemSpider	33876 Y
UNII	F93UJX4SWT
KEGG	D08593 Y
ChEBI	CHEBI:9587 Y
ChEMBL	ChEMBL1449 Y
CompTox Dashboard (EPA)	DTXSID0023668
ECHA InfoCard	100.047.451
Chemical and physical data
Formula	C15H16N2O6S2
Molar mass	384.42 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(O)[C@@H]2N3C(=O)[C@@H](NC(=O)[C@@H](c1ccsc1)C(=O)O)[C@H]3SC2(C)C
InChI InChI=1S/C15H16N2O6S2/c1-15(2)9(14(22)23)17-11(19)8(12(17)25-15)16-10(18)7(13(20)21)6-3-4-24-5-6/h3-5,7-9,12H,1-2H3,(H,16,18)(H,20,21)(H,22,23)/t7-,8-,9+,12-/m1/s1 Y Key:OHKOGUYZJXTSFX-KZFFXBSXSA-N Y
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Ticarcillin is a carboxypenicillin. It can be sold and used in combination with clavulanate as ticarcillin/clavulanic acid. Because it is a penicillin, it also falls within the larger class of β-lactam antibiotics. Its main clinical use is as an injectable antibiotic for the treatment of Gram-negative bacteria, particularly Pseudomonas aeruginosa and Proteus vulgaris. It is also one of the few antibiotics capable of treating Stenotrophomonas maltophilia infections.

It is provided as a white or pale-yellow powder. It is highly soluble in water, but should be dissolved only immediately before use to prevent degradation.

It was patented in 1963.^[1]