Tissue factor

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F3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AHW, 1BOY, 1DAN, 1FAK, 1J9C, 1JPS, 1O5D, 1TFH, 1UJ3, 1W0Y, 1W2K, 1WQV, 1WSS, 1WTG, 1WUN, 1WV7, 1Z6J, 2A2Q, 2AEI, 2AER, 2B7D, 2B8O, 2C4F, 2CEF, 2CEH, 2CEZ, 2CFJ, 2EC9, 2F9B, 2FIR, 2FLB, 2HFT, 2PUQ, 2ZP0, 2ZWL, 2ZZU, 3ELA, 3TH2, 3TH3, 3TH4, 4IBL, 4M7L, 4Z6A, 4ZMA, 4YLQ, 2FLR
Identifiers
Aliases	F3, CD142, TF, TFA, coagulation factor III, tissue factor
External IDs	OMIM: 134390; MGI: 88381; HomoloGene: 1511; GeneCards: F3; OMA:F3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p21.3 Start 94,529,173 bp[1] End 94,541,759 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 G1|3 52.94 cM Start 121,517,186 bp[2] End 121,528,697 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of paranasal sinus palpebral conjunctiva nasal epithelium olfactory zone of nasal mucosa amniotic fluid stromal cell of endometrium left uterine tube lower lobe of lung gallbladder left ovary Top expressed in Eustachian tube corneal stroma skin of external ear cervix tunica adventitia of aorta respiratory epithelium olfactory epithelium esophagus conjunctival fornix deep cerebellar nuclei More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding cytokine receptor activity phospholipid binding serine-type endopeptidase activity protease binding Cellular component membrane extracellular matrix intrinsic component of external side of plasma membrane plasma membrane extracellular region extracellular exosome cell surface extracellular space serine-type peptidase complex integral component of membrane collagen-containing extracellular matrix Biological process hemostasis positive regulation of protein kinase B signaling positive regulation of endothelial cell proliferation cytokine-mediated signaling pathway positive regulation of cell migration activation of blood coagulation via clotting cascade positive regulation of platelet-derived growth factor receptor signaling pathway positive regulation of angiogenesis blood coagulation, extrinsic pathway activation of plasma proteins involved in acute inflammatory response activation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of positive chemotaxis blood coagulation protein processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2152 14066 Ensembl ENSG00000117525 ENSMUSG00000028128 UniProt P13726 P20352 RefSeq (mRNA) NM_001993 NM_001178096 NM_010171 RefSeq (protein) NP_001171567 NP_001984 NP_034301 Location (UCSC) Chr 1: 94.53 – 94.54 Mb Chr 3: 121.52 – 121.53 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Tissue factor, also called platelet tissue factor or Coagulation factor III,^[5] is a protein present in subendothelial tissue and leukocytes which plays a major role in coagulation and, in humans, is encoded by F3 gene. Its role in the blood clotting is the initiation of thrombin formation from the zymogen prothrombin. Thromboplastin defines the cascade that leads to the activation of factor X—the tissue factor pathway. In doing so, it has replaced the previously named extrinsic pathway in order to eliminate ambiguity.