Toll-like receptor 1

TLR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Z7X, 1FYV
Identifiers
Aliases	TLR1, CD281, TIL, TIL. LPRS5, rsc786, toll like receptor 1
External IDs	OMIM: 601194; MGI: 1341295; HomoloGene: 20694; GeneCards: TLR1; OMA:TLR1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p14 Start 38,790,677 bp[1] End 38,856,817 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 C3.1|5 33.53 cM Start 65,082,022 bp[2] End 65,090,906 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood bone marrow cells Achilles tendon granulocyte appendix gallbladder spleen lymph node periodontal fiber Top expressed in mesenteric lymph nodes left colon spleen blood submandibular gland external carotid artery internal carotid artery subcutaneous adipose tissue stroma of bone marrow cervix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function Toll-like receptor 2 binding protein binding protein heterodimerization activity lipopeptide binding transmembrane signaling receptor activity signaling receptor activity identical protein binding Cellular component integral component of membrane phagocytic vesicle membrane Golgi apparatus membrane plasma membrane Toll-like receptor 1-Toll-like receptor 2 protein complex integral component of plasma membrane membrane raft cytoplasmic vesicle Biological process defense response toll-like receptor TLR1:TLR2 signaling pathway immune system process MyD88-dependent toll-like receptor signaling pathway cellular response to triacyl bacterial lipopeptide detection of triacyl bacterial lipopeptide toll-like receptor 1 signaling pathway macrophage activation inflammatory response signal transduction innate immune response defense response to bacterium cell activation toll-like receptor signaling pathway immune response positive regulation of toll-like receptor 2 signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7096 21897 Ensembl ENSG00000174125 ENSMUSG00000044827 UniProt Q15399 Q9EPQ1 RefSeq (mRNA) NM_003263 NM_001276445 NM_030682 RefSeq (protein) NP_003254 NP_001263374 NP_109607 Location (UCSC) Chr 4: 38.79 – 38.86 Mb Chr 5: 65.08 – 65.09 Mb PubMed search [3] [4]
Wikidata
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Toll-like receptor 1 (TLR1) is a member of Toll-like receptors (TLRs), which is a family of pattern recognition receptors (PRRs) that form the cornerstone of the innate immune system.^[5][6][7] TLR1 recognizes bacterial lipoproteins and glycolipids in complex with TLR2. TLR1 is a cell surface receptor.^[5] TLR1 is in humans encoded by the TLR1 gene, which is located on chromosome 4.^[8]