Toll-like receptor 2

TLR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FYW, 1FYX, 1O77, 2Z7X, 2Z80
Identifiers
Aliases	TLR2, CD282, TIL4, toll like receptor 2
External IDs	OMIM: 603028; MGI: 1346060; HomoloGene: 20695; GeneCards: TLR2; OMA:TLR2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q31.3 Start 153,684,070 bp[1] End 153,706,260 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 E3 Start 83,743,579 bp[2] End 83,749,074 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood granulocyte right lung upper lobe of left lung spleen bone marrow cartilage tissue bone marrow cells periodontal fiber Top expressed in granulocyte stroma of bone marrow right lung lobe tibiofemoral joint calvaria islet of Langerhans conjunctival fornix epithelium of lens cervix vestibular membrane of cochlear duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function pattern recognition receptor activity lipopolysaccharide binding Toll-like receptor binding triacyl lipopeptide binding protein binding peptidoglycan binding protein heterodimerization activity lipopolysaccharide immune receptor activity transmembrane signaling receptor activity lipopeptide binding Cellular component cytoplasm integral component of membrane phagocytic vesicle membrane Golgi apparatus membrane intrinsic component of plasma membrane plasma membrane Toll-like receptor 1-Toll-like receptor 2 protein complex integral component of plasma membrane membrane raft cytoplasmic vesicle cell projection cell surface cell body Biological process interleukin-10 production positive regulation of interferon-beta production defense response to Gram-positive bacterium positive regulation of interleukin-18 production positive regulation of toll-like receptor signaling pathway toll-like receptor TLR1:TLR2 signaling pathway positive regulation of inflammatory response cellular response to bacterial lipopeptide positive regulation of interleukin-12 production immune system process detection of diacyl bacterial lipopeptide cellular response to diacyl bacterial lipopeptide I-kappaB phosphorylation positive regulation of nitric-oxide synthase biosynthetic process MyD88-dependent toll-like receptor signaling pathway cellular response to triacyl bacterial lipopeptide detection of triacyl bacterial lipopeptide positive regulation of Wnt signaling pathway positive regulation of gene expression cellular response to lipoteichoic acid positive regulation of NF-kappaB transcription factor activity immune response positive regulation of interleukin-8 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of chemokine production innate immune response inflammatory response toll-like receptor TLR6:TLR2 signaling pathway response to molecule of bacterial origin signal transduction positive regulation of transcription by RNA polymerase II apoptotic process response to lipopolysaccharide response to progesterone toll-like receptor signaling pathway response to insulin central nervous system myelin formation nitric oxide metabolic process response to fatty acid leukotriene metabolic process toll-like receptor 2 signaling pathway positive regulation of oligodendrocyte differentiation response to bacterial lipoprotein negative regulation of cell population proliferation response to toxic substance response to hypoxia positive regulation of interleukin-10 production lipopolysaccharide-mediated signaling pathway microglial cell activation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7097 24088 Ensembl ENSG00000137462 ENSMUSG00000027995 UniProt O60603 Q9QUN7 RefSeq (mRNA) NM_003264 NM_001318787 NM_001318789 NM_001318790 NM_001318791 NM_001318793 NM_001318795 NM_001318796 NM_011905 RefSeq (protein) NP_001305716 NP_001305718 NP_001305719 NP_001305720 NP_001305722 NP_001305724 NP_001305725 NP_003255 NP_036035 Location (UCSC) Chr 4: 153.68 – 153.71 Mb Chr 3: 83.74 – 83.75 Mb PubMed search [3] [4]
Wikidata
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Toll-like receptor 2 also known as TLR2 is a protein that in humans is encoded by the TLR2 gene.^[5] TLR2 has also been designated as CD282 (cluster of differentiation 282). TLR2 is one of the toll-like receptors and plays a role in the immune system. TLR2 is a membrane protein, a receptor, which is expressed on the surface of certain cells and recognizes foreign substances and passes on appropriate signals to the cells of the immune system.