Toll-like receptor 3

TLR3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZIW, 2A0Z, 3ULU, 3ULV, 2MK9, 2MKA
Identifiers
Aliases	TLR3, CD283, IIAE2, toll like receptor 3, IMD83
External IDs	OMIM: 603029; MGI: 2156367; HomoloGene: 20696; GeneCards: TLR3; OMA:TLR3 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q35.1 Start 186,069,155 bp[1] End 186,088,073 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 B1.1 Start 45,848,702 bp[2] End 45,864,117 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa palpebral conjunctiva placenta rectum sperm duodenum gallbladder Achilles tendon epithelium of colon pancreatic epithelial cell Top expressed in conjunctival fornix gastrula stria vascularis transitional epithelium of urinary bladder vestibular membrane of cochlear duct vestibular sensory epithelium secondary oocyte lumbar subsegment of spinal cord Epithelium of choroid plexus jejunum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding identical protein binding RNA binding double-stranded RNA binding transmembrane signaling receptor activity signaling receptor activity Cellular component cytoplasm integral component of membrane endosome endoplasmic reticulum membrane membrane Golgi membrane integral component of plasma membrane intracellular anatomical structure cell surface lysosomal membrane early endosome endoplasmic reticulum endolysosome membrane endosome membrane extracellular space extracellular matrix Biological process positive regulation of interferon-beta production response to dsRNA defense response positive regulation of toll-like receptor signaling pathway positive regulation of protein phosphorylation male gonad development positive regulation of inflammatory response positive regulation of interleukin-12 production positive regulation of type III interferon production cellular response to interferon-beta response to exogenous dsRNA negative regulation of osteoclast differentiation positive regulation of cytokine production immune system process response to virus activation of NF-kappaB-inducing kinase activity I-kappaB phosphorylation positive regulation of JNK cascade hyperosmotic response cellular response to dsRNA regulation of dendritic cell cytokine production microglial cell activation toll-like receptor signaling pathway TRIF-dependent toll-like receptor signaling pathway cellular response to mechanical stimulus microglial cell activation involved in immune response positive regulation of gene expression defense response to bacterium positive regulation of NF-kappaB transcription factor activity defense response to virus necroptotic signaling pathway positive regulation of interleukin-8 production cellular response to exogenous dsRNA positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production cellular response to interferon-gamma positive regulation of chemokine production positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling detection of virus inflammatory response innate immune response I-kappaB kinase/NF-kappaB signaling toll-like receptor 3 signaling pathway positive regulation of type I interferon production MyD88-independent toll-like receptor signaling pathway signal transduction positive regulation of transcription by RNA polymerase II necroptosis apoptotic signaling pathway negative regulation of MyD88-independent toll-like receptor signaling pathway extrinsic apoptotic signaling pathway positive regulation of angiogenesis positive regulation of NIK/NF-kappaB signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7098 142980 Ensembl ENSG00000164342 ENSMUSG00000031639 UniProt O15455 Q99MB1 RefSeq (mRNA) NM_003265 NM_126166 NM_001357316 NM_001357317 RefSeq (protein) NP_003256 NP_569054 NP_001344245 NP_001344246 Location (UCSC) Chr 4: 186.07 – 186.09 Mb Chr 8: 45.85 – 45.86 Mb PubMed search [3] [4]
Wikidata
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Toll-like receptor 3 (TLR3) also known as CD283 (cluster of differentiation 283) is a protein that in humans is encoded by the TLR3 gene.^[5] TLR3 is a member of the toll-like receptor family of pattern recognition receptors of the innate immune system. TLR3 recognizes double-stranded RNA in endosomes, which is a common feature of viral genomes internalised by macrophages and dendritic cells.