Toll-like receptor 7

TLR7
Identifiers
Aliases	TLR7, TLR7-like, toll like receptor 7, IMD74, SLEB17
External IDs	OMIM: 300365; MGI: 2176882; HomoloGene: 75060; GeneCards: TLR7; OMA:TLR7 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp22.2 Start 12,867,072 bp[1] End 12,890,361 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X F5 Start 166,087,925 bp[2] End 166,113,554 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte testicle lymph node appendix gallbladder parietal pleura rectum right coronary artery placenta Top expressed in stroma of bone marrow granulocyte spleen calvaria blood embryo embryo mesenteric lymph nodes subcutaneous adipose tissue thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transmembrane signaling receptor activity double-stranded RNA binding siRNA binding single-stranded RNA binding pattern recognition receptor activity Cellular component integral component of membrane Golgi membrane cytoplasmic vesicle early phagosome endosome receptor complex phagocytic vesicle membrane lysosome endoplasmic reticulum plasma membrane endolysosome membrane cytoplasm endosome membrane endoplasmic reticulum membrane Biological process I-kappaB phosphorylation immune system process positive regulation of inflammatory response toll-like receptor 9 signaling pathway positive regulation of interleukin-8 production toll-like receptor signaling pathway regulation of protein phosphorylation defense response to virus cellular response to mechanical stimulus microglial cell activation positive regulation of interleukin-6 production MyD88-dependent toll-like receptor signaling pathway signal transduction positive regulation of chemokine production immune response toll-like receptor 7 signaling pathway innate immune response inflammatory response positive regulation of NIK/NF-kappaB signaling I-kappaB kinase/NF-kappaB signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51284 170743 Ensembl ENSG00000196664 ENSMUSG00000044583 UniProt Q9NYK1 P58681 RefSeq (mRNA) NM_016562 NM_133211 NM_001290755 NM_001290756 NM_001290757 NM_001290758 RefSeq (protein) NP_057646 NP_001277684 NP_001277685 NP_001277686 NP_001277687 NP_573474 Location (UCSC) Chr X: 12.87 – 12.89 Mb Chr X: 166.09 – 166.11 Mb PubMed search [3] [4]
Wikidata
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Toll-like receptor 7, also known as TLR7, is a protein that in humans is encoded by the TLR7 gene. Orthologs are found in mammals and birds.^[5] It is a member of the toll-like receptor (TLR) family and detects single stranded RNA.