Toll-like receptor 8

TLR8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3W3G, 3W3J, 3W3K, 3W3L, 3W3M, 3W3N, 3WN4, 4QBZ, 4QC0, 4R07, 4R08, 4R09, 4R0A, 4R6A, 5AWB, 5AWD, 5HDH, 5AWA
Identifiers
Aliases	TLR8, CD288, toll like receptor 8, hIMD98
External IDs	OMIM: 300366; MGI: 2176887; HomoloGene: 44054; GeneCards: TLR8; OMA:TLR8 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp22.2 Start 12,906,620 bp[1] End 12,923,169 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X F5 Start 166,025,692 bp[2] End 166,047,325 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood granulocyte visceral pleura trabecular bone bone marrow spleen appendix parietal pleura lower lobe of lung Top expressed in granulocyte zygote embryo stroma of bone marrow secondary oocyte calvaria esophagus muscle of thigh spleen blastocyst More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding identical protein binding RNA binding double-stranded RNA binding single-stranded RNA binding transmembrane signaling receptor activity signaling receptor activity pattern recognition receptor activity Cellular component endoplasmic reticulum membrane membrane Golgi membrane endolysosome membrane endosome membrane integral component of plasma membrane external side of plasma membrane integral component of membrane plasma membrane Biological process regulation of protein phosphorylation immune system process response to virus MyD88-dependent toll-like receptor signaling pathway microglial cell activation cellular response to mechanical stimulus defense response to virus immunoglobulin mediated immune response positive regulation of innate immune response toll-like receptor 9 signaling pathway I-kappaB kinase/NF-kappaB signaling signal transduction innate immune response inflammatory response toll-like receptor signaling pathway toll-like receptor 8 signaling pathway immune response positive regulation of interleukin-6 production Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51311 170744 Ensembl ENSG00000101916 ENSMUSG00000040522 UniProt Q9NR97 P58682 RefSeq (mRNA) NM_016610 NM_138636 NM_133212 NM_001313760 NM_001313761 RefSeq (protein) NP_057694 NP_619542 NP_001300689 NP_001300690 NP_573475 Location (UCSC) Chr X: 12.91 – 12.92 Mb Chr X: 166.03 – 166.05 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Toll-like receptor 8 is a protein that in humans is encoded by the TLR8 gene.^[5] TLR8 has also been designated as CD288 (cluster of differentiation 288). It is a member of the toll-like receptor (TLR) family.