Tumor necrosis factor receptor 1

TNFRSF1A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1EXT, 1FT4, 1ICH, 1NCF, 1TNR
Identifiers
Aliases	TNFRSF1A, CD120a, FPF, MS5, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR1-d2, TNFR55, TNFR60, p55, p55-R, p60, tumor necrosis factor receptor superfamily member 1A, TNF receptor superfamily member 1A
External IDs	OMIM: 191190; MGI: 1314884; HomoloGene: 828; GeneCards: TNFRSF1A; OMA:TNFRSF1A - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	6,342,114 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	125,339,447 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; gallbladder; ; left uterine tube; ; epithelium of colon; ; right coronary artery; ; upper lobe of left lung; ; left adrenal cortex; ; Descending thoracic aorta; ; pericardium; ; blood;
	Top expressed in
	granulocyte; ; tibiofemoral joint; ; saccule; ; lip; ; stroma of bone marrow; ; otic placode; ; esophagus; ; calvaria; ; otic vesicle; ; ankle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; tumor necrosis factor-activated receptor activity; tumor necrosis factor binding; identical protein binding;
Cellular component	integral component of membrane; Golgi apparatus; membrane; Golgi membrane; receptor complex; plasma membrane; integral component of plasma membrane; extracellular region; cell surface; mitochondrion; membrane raft; extracellular space; tumor necrosis factor receptor superfamily complex;
Biological process	regulation of apoptotic process; prostaglandin metabolic process; defense response; positive regulation of ceramide biosynthetic process; positive regulation of inflammatory response; regulation of tumor necrosis factor-mediated signaling pathway; tumor necrosis factor-mediated signaling pathway; response to lipopolysaccharide; cellular response to mechanical stimulus; death-inducing signaling complex assembly; regulation of cell population proliferation; defense response to bacterium; immune response; intrinsic apoptotic signaling pathway in response to DNA damage; positive regulation of I-kappaB kinase/NF-kappaB signaling; viral process; I-kappaB kinase/NF-kappaB signaling; negative regulation of inflammatory response; regulation of establishment of endothelial barrier; extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of transcription by RNA polymerase II; signal transduction; apoptotic process; inflammatory response; cell surface receptor signaling pathway; positive regulation of tyrosine phosphorylation of STAT protein; protein localization to plasma membrane; cytokine-mediated signaling pathway; aortic valve development; pulmonary valve development; negative regulation of extracellular matrix constituent secretion; negative regulation of cardiac muscle hypertrophy; positive regulation of apoptotic process involved in morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	7132
	21937
	ENSG00000067182
	ENSMUSG00000030341
	P19438
	P25118
	NM_001065; NM_001346091; NM_001346092
	NM_011609
	NP_001056; NP_001333020; NP_001333021
	NP_035739
	Wikidata
View/Edit Human	View/Edit Mouse

Tumor necrosis factor receptor 1 (TNFR1), also known as tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) and CD120a, is a ubiquitous membrane receptor that binds tumor necrosis factor-alpha (TNFα).^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000067182 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030341 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Baker E, Chen LZ, Smith CA, Callen DF, Goodwin R, Sutherland GR (November 1991). "Chromosomal location of the human tumor necrosis factor receptor genes". Cytogenet Cell Genet. 57 (2–3): 117–8. doi:10.1159/000133127. PMID 1655358.
^ Schall TJ, Lewis M, Koller KJ, Lee A, Rice GC, Wong GH, Gatanaga T, Granger GA, Lentz R, Raab H, et al. (June 1990). "Molecular cloning and expression of a receptor for human tumor necrosis factor". Cell. 61 (2): 361–70. doi:10.1016/0092-8674(90)90816-W. PMID 2158863. S2CID 36187863.
^ Offermanns S, Rosenthal W (2008). Encyclopedia of Molecular Pharmacology, Vol. 1 (2nd ed.). Heidelberg, Germany: Springer. p. 1248. ISBN 9783540389163.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000067182 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030341 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1655358-5] Baker E, Chen LZ, Smith CA, Callen DF, Goodwin R, Sutherland GR (November 1991). "Chromosomal location of the human tumor necrosis factor receptor genes". Cytogenet Cell Genet. 57 (2–3): 117–8. doi:10.1159/000133127. PMID 1655358.

[pmid2158863-6] Schall TJ, Lewis M, Koller KJ, Lee A, Rice GC, Wong GH, Gatanaga T, Granger GA, Lentz R, Raab H, et al. (June 1990). "Molecular cloning and expression of a receptor for human tumor necrosis factor". Cell. 61 (2): 361–70. doi:10.1016/0092-8674(90)90816-W. PMID 2158863. S2CID 36187863.

[7] Offermanns S, Rosenthal W (2008). Encyclopedia of Molecular Pharmacology, Vol. 1 (2nd ed.). Heidelberg, Germany: Springer. p. 1248. ISBN 9783540389163.

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