U.S. Route 221 in Virginia

U.S. Route 221
US 221 highlighted in red
Route information
Auxiliary route of US 21
Maintained by VDOT
Length	149.61 mi[1] (240.77 km)
Major junctions
South end	US 21 / US 221 near Independence
Major intersections	US 21 / US 58 in Independence SR 89 in Galax I-77 near Hillsville US 52 in Hillsville US 58 in Hillsville SR 8 in Floyd Future I-73 / I-581 / US 220 in Roanoke US 11 / US 460 in Roanoke US 460 in Bedford US 501 in Lynchburg
North end	US 29 Bus. / US 460 Bus. / US 501 Bus. in Lynchburg
Location
Country	United States
State	Virginia
Counties	Grayson, City of Galax, Carroll, Floyd, Roanoke, City of Roanoke, Botetourt, Bedford, City of Lynchburg
Highway system
United States Numbered Highway System List Special Divided Virginia Routes Interstate US Primary Secondary Byways History HOT lanes
← US 220 → SR 222

U.S. Route 221 (US 221) is a part of the U.S. Highway System that runs from Perry, Florida to Lynchburg, Virginia. In Virginia, the U.S. Highway runs 149.61 miles (240.77 km) from the North Carolina state line near Independence north to its northern terminus at US 29 Business, US 460 Business, and US 501 Business in Lynchburg. US 221 connects Independence, Galax, and Hillsville in Southwest Virginia while running concurrently with US 58. The U.S. Highway connects those communities with Roanoke via Floyd County, within which US 221 is the main east–west highway. Entering Bedford County, US 221 exits the Blue Ridge Mountains; it then passes through the Piedmont town of Bedford on its way to Lynchburg and shares a brief overlap with US 460 Business through the town. The U.S. Highway also runs concurrently with US 460 from Roanoke to Bedford and parallels that U.S. Highway from Bedford to Lynchburg.