U.S. Route 64 in North Carolina

U.S. Highway 64
Route of US 64 in North Carolina highlighted in red
Route information
Maintained by NCDOT
Length	604 mi[1][2] (972 km)
Existed	1932–present
Tourist routes	Mountain Waters Scenic Byway Waterfall Byway Black Mountain Rag Alligator River Route Roanoke Voyages Corridor
Major junctions
West end	US 64 / US 74 / SR 40 at the Tennessee state line
Major intersections	US 23 / US 441 in Franklin I-26 / US 25 / US 74 in Hendersonville US 321 in Lenoir US 52 in Lexington I-85 near Lexington I-73 / I-74 / US 220 in Asheboro I-40 / I-87 / I-440 in Raleigh I-540 in Knightdale I-95 in Rocky Mount US 13 / US 17 in Williamston
East end	US 158 / NC 12 at Whalebone Junction
Location
Country	United States
State	North Carolina
Counties	Cherokee, Clay, Macon, Jackson, Transylvania, Henderson, Rutherford, McDowell, Burke, Caldwell, Alexander, Iredell, Davie, Davidson, Randolph, Chatham, Wake, Franklin, Nash, Edgecombe, Martin, Washington, Tyrrell, Dare
Highway system
United States Numbered Highway System List Special Divided North Carolina Highway System Interstate US State Scenic
← NC 63 → NC 65

U.S. Route 64 (US 64) is the longest numbered route in the U.S. state of North Carolina, running 604 miles (972 km) from the Tennessee state line to the Outer Banks. The route passes through the westernmost municipality in the state, Murphy, and one of the most easternmost municipalities, Manteo, making US 64 a symbolic representation of the phrase "from Murphy to Manteo" which is used to refer to the expanse of the state. The highway is a major east–west route through the central and eastern portion of the state.