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Valsartan

Valsartan
Clinical data
Trade namesDiovan, others
AHFS/Drugs.comMonograph
MedlinePlusa697015
License data
Pregnancy
category
Routes of
administration		By mouth
Drug classAngiotensin II receptor antagonist
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability25%
Protein binding95%
Elimination half-life6 hours
ExcretionKidney 30%, bile duct 70%
Identifiers
  • (S)-3-methyl-2-(N-{[2'-(2H-1,2,3,4-tetrazol-5-yl)biphenyl-4-yl]methyl}pentanamido)butanoic acid
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.113.097 Edit this at Wikidata
Chemical and physical data
FormulaC24H29N5O3
Molar mass435.528 g·mol−1
3D model (JSmol)
  • CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)C(C(=O)O)C(C)C
  • InChI=1S/C24H29N5O3/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28)/t22-/m0/s1 checkY
  • Key:ACWBQPMHZXGDFX-QFIPXVFZSA-N checkY
  (verify)

Valsartan, sold under the brand name Diovan among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease.[8] It belongs to a class of medications referred to as angiotensin II receptor blockers (ARBs). It is a reasonable initial treatment for high blood pressure.[8] It is taken by mouth.[8]

Common side effects include feeling tired, dizziness, high blood potassium, diarrhea, and joint pain.[8] Other serious side effects may include kidney problems, low blood pressure, and angioedema.[8] Use in pregnancy may harm the baby and use when breastfeeding is not recommended.[9] It is an angiotensin II receptor antagonist and works by blocking the effects of angiotensin II.[8]

Valsartan was patented in 1990, and came into medical use in 1996.[10] It is available as a generic medication.[11] In 2021, it was the 120th most commonly prescribed medication in the United States, with more than 5 million prescriptions.[12][13] Versions are available as the combinations valsartan/hydrochlorothiazide,[14] valsartan/amlodipine,[15] valsartan/amlodipine/hydrochlorothiazide,[16] valsartan/nebivolol,[17] and valsartan/sacubitril.[8][18]

  1. ^ "Valsartan Use During Pregnancy". Drugs.com. 28 March 2019. Retrieved 12 February 2020.
  2. ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
  3. ^ "Diovan valsartan 40mg film-coated tablet blister pack". Therapeutic Goods Administration (TGA). Archived from the original on 25 October 2021. Retrieved 24 October 2021.
  4. ^ "Diovan valsartan 80mg film-coated tablet blister pack". Therapeutic Goods Administration (TGA). Archived from the original on 25 October 2021. Retrieved 24 October 2021.
  5. ^ "Diovan valsartan 160mg film-coated tablet blister pack". Therapeutic Goods Administration (TGA). Archived from the original on 25 October 2021. Retrieved 24 October 2021.
  6. ^ "Valsartan 160 mg capsules - Summary of Product Characteristics (SmPC)". (emc). 19 February 2019. Archived from the original on 13 February 2020. Retrieved 12 February 2020.
  7. ^ Cite error: The named reference Diovan FDA label was invoked but never defined (see the help page).
  8. ^ a b c d e f g "Valsartan Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
  9. ^ "Valsartan Pregnancy and Breastfeeding Warnings". Drugs.com. Retrieved 3 March 2019.
  10. ^ Fischer J, Ganellin CR, eds. (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 470. ISBN 9783527607495.
  11. ^ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 179. ISBN 9780857113382.
  12. ^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
  13. ^ "Valsartan - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
  14. ^ "Valsartan and hydrochlorothiazide Advanced Patient Information". Drugs.com. 29 January 2024. Retrieved 7 February 2024.
  15. ^ "Amlodipine and valsartan Advanced Patient Information". Drugs.com. 27 June 2023. Retrieved 7 February 2024.
  16. ^ "Amlodipine, valsartan, and hydrochlorothiazide Advanced Patient Information". Drugs.com. 2 December 2023. Retrieved 7 February 2024.
  17. ^ "Nebivolol and valsartan Advanced Patient Information". Drugs.com. 14 October 2023. Retrieved 7 February 2024.
  18. ^ "Sacubitril and Valsartan Monograph for Professionals". Drugs.com. 7 November 2019. Retrieved 12 February 2020.

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