Vascular endothelial growth factor A

VEGFA
Available structures
PDB	Ortholog search: H0YBI8 PDBe H0YBI8 RCSB
List of PDB id codes
	1BJ1, 1CZ8, 1FLT, 1KAT, 1KMX, 1MJV, 1MKG, 1MKK, 1QTY, 1TZH, 1TZI, 1VGH, 1VPF, 1VPP, 2FJG, 2FJH, 2QR0, 2VGH, 2VPF, 3BDY, 3P9W, 3QTK, 3S1B, 3S1K, 3V2A, 4DEQ, 4GLN, 4GLS, 4KZN, 4QAF, 4WPB, 4ZFF, 5HHC, 5FV1, 5FV2, 5HHD, 5DN2
Identifiers
Aliases	VEGFA, MVCD1, VEGF, VPF, vascular endothelial growth factor A
External IDs	OMIM: 192240; MGI: 103178; HomoloGene: 2534; GeneCards: VEGFA; OMA:VEGFA - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	43,786,487 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	46,343,295 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; left lobe of thyroid gland; ; glomerulus; ; metanephric glomerulus; ; retinal pigment epithelium; ; cartilage tissue; ; right lobe of liver; ; apex of heart; ; pericardium; ; right auricle;
	Top expressed in
	neural layer of retina; ; muscle of thigh; ; left lung lobe; ; gastrula; ; right lung; ; submandibular gland; ; islet of Langerhans; ; brown adipose tissue; ; right lung lobe; ; adrenal gland;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	heparin binding; extracellular matrix binding; cytokine activity; growth factor activity; neuropilin binding; vascular endothelial growth factor receptor 2 binding; receptor ligand activity; vascular endothelial growth factor receptor 1 binding; protein homodimerization activity; platelet-derived growth factor receptor binding; protein binding; vascular endothelial growth factor receptor binding; fibronectin binding; chemoattractant activity; identical protein binding; protein heterodimerization activity;
Cellular component	cytoplasm; membrane; extracellular region; cell surface; secretory granule; platelet alpha granule lumen; extracellular space; extracellular matrix;
Biological process	cardiac vascular smooth muscle cell development; positive regulation of protein phosphorylation; positive regulation of MAP kinase activity; vascular endothelial growth factor signaling pathway; positive regulation of receptor internalization; outflow tract morphogenesis; mammary gland alveolus development; monocyte differentiation; cell migration involved in sprouting angiogenesis; vasculogenesis; positive regulation of retinal ganglion cell axon guidance; vascular endothelial growth factor receptor signaling pathway; positive regulation of vascular permeability; positive regulation of mesenchymal cell proliferation; angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of ERK1 and ERK2 cascade; mesoderm development; positive regulation of positive chemotaxis; positive regulation of p38MAPK cascade; positive regulation of neuroblast proliferation; dopaminergic neuron differentiation; positive regulation of branching involved in ureteric bud morphogenesis; kidney development; lung development; coronary artery morphogenesis; in utero embryonic development; cell maturation; commissural neuron axon guidance; positive regulation of peptidyl-serine phosphorylation; positive regulation of CREB transcription factor activity; basophil chemotaxis; artery morphogenesis; regulation of transcription from RNA polymerase II promoter in response to hypoxia; positive regulation of peptidyl-tyrosine autophosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; branching involved in blood vessel morphogenesis; positive regulation of protein localization to early endosome; primitive erythrocyte differentiation; positive regulation of protein kinase D signaling; lactation; cell differentiation; epithelial cell differentiation; positive regulation of leukocyte migration; positive regulation of epithelial cell proliferation; negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; nervous system development; macrophage differentiation; positive regulation of angiogenesis; regulation of retinal ganglion cell axon guidance; lymph vessel morphogenesis; post-embryonic camera-type eye development; regulation of cell shape; ovarian follicle development; branching morphogenesis of an epithelial tube; coronary vein morphogenesis; surfactant homeostasis; positive regulation of vascular endothelial growth factor receptor signaling pathway; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; response to hypoxia; positive regulation of endothelial cell proliferation; positive regulation of protein-containing complex assembly; positive regulation of protein kinase C signaling; positive regulation of cell migration; heart morphogenesis; platelet degranulation; positive regulation of axon extension involved in axon guidance; positive regulation of endothelial cell migration; multicellular organism development; positive regulation of histone deacetylase activity; tube formation; positive regulation of gene expression; positive regulation of protein autophosphorylation; endothelial cell chemotaxis; positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; eye photoreceptor cell development; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; positive regulation of focal adhesion assembly; cellular response to vascular endothelial growth factor stimulus; activation of protein kinase activity; positive regulation of cell division; camera-type eye morphogenesis; positive regulation of transcription by RNA polymerase II; positive regulation of cell adhesion; cellular response to hypoxia; positive chemotaxis; regulation of transcription by RNA polymerase II; positive regulation of cell population proliferation; induction of positive chemotaxis; positive regulation of mast cell chemotaxis; motor neuron migration; positive regulation of tyrosine phosphorylation of STAT protein; growth; VEGF-activated neuropilin signaling pathway; positive regulation of phosphorylation; regulation of signaling receptor activity; negative regulation of gene expression; cytokine-mediated signaling pathway; positive regulation of cell migration involved in sprouting angiogenesis; cellular stress response to acid chemical; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; positive regulation of sprouting angiogenesis; positive regulation of DNA biosynthetic process; sprouting angiogenesis; regulation of nitric oxide mediated signal transduction; positive regulation of cold-induced thermogenesis; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	7422
	22339
	ENSG00000112715
	ENSMUSG00000023951
	P15692
	Q00731
NM_003376; NM_001025366; NM_001025367; NM_001025368; NM_001025369;
	NM_001025370; NM_001033756; NM_001171622; NM_001171623; NM_001171624; NM_001171625; NM_001171626; NM_001171627; NM_001171628; NM_001171629; NM_001171630; NM_001204384; NM_001204385; NM_001287044; NM_001317010
NM_001025250; NM_001025257; NM_001110266; NM_001110267; NM_001110268;
	NM_001287056; NM_001287057; NM_001287058; NM_009505; NM_001317041
NP_001020537; NP_001020538; NP_001020539; NP_001020540; NP_001020541;
	NP_001028928; NP_001165093; NP_001165094; NP_001165095; NP_001165096; NP_001165097; NP_001165098; NP_001165099; NP_001165100; NP_001165101; NP_001191313; NP_001191314; NP_001273973; NP_001303939; NP_003367
NP_001020421; NP_001020428; NP_001103736; NP_001103737; NP_001103738;
	NP_001273985; NP_001273986; NP_001273987; NP_001303970; NP_033531
	Wikidata
View/Edit Human	View/Edit Mouse

Vascular endothelial growth factor A (VEGF-A) is a protein that in humans is encoded by the VEGFA gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112715 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023951 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mattei MG, Borg JP, Rosnet O, Marmé D, Birnbaum D (February 1996). "Assignment of vascular endothelial growth factor (VEGF) and placenta growth factor (PLGF) genes to human chromosome 6p12-p21 and 14q24-q31 regions, respectively". Genomics. 32 (1): 168–169. doi:10.1006/geno.1996.0098. PMID 8786112.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112715 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023951 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8786112-5] Mattei MG, Borg JP, Rosnet O, Marmé D, Birnbaum D (February 1996). "Assignment of vascular endothelial growth factor (VEGF) and placenta growth factor (PLGF) genes to human chromosome 6p12-p21 and 14q24-q31 regions, respectively". Genomics. 32 (1): 168–169. doi:10.1006/geno.1996.0098. PMID 8786112.

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