Vinculin

VCL
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1RKC, 1RKE, 1SYQ, 1TR2, 2GWW, 2IBF, 3H2U, 3H2V, 3MYI, 3TJ5, 3TJ6, 3VF0, 4DJ9, 4EHP, 1YDI, 2HSQ, 3RF3, 3S90, 4LN2, 4LNP, 4PR9, 3JBK
Identifiers
Aliases	VCL, CMD1W, CMH15, HEL114, MV, Mvinculin
External IDs	OMIM: 193065; MGI: 98927; HomoloGene: 7594; GeneCards: VCL; OMA:VCL - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q22.2 Start 73,995,193 bp[1] End 74,121,363 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 A3|14 11.53 cM Start 20,979,466 bp[2] End 21,083,744 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein urethra vena cava smooth muscle tissue right coronary artery popliteal artery tibial arteries nipple seminal vesicula Descending thoracic aorta Top expressed in tunica media of zone of aorta calvaria endothelial cell of lymphatic vessel tibiofemoral joint belly cord ascending aorta right lung left lung carotid body left lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function beta-catenin binding dystroglycan binding structural molecule activity protein binding actin binding alpha-catenin binding ubiquitin protein ligase binding cadherin binding Cellular component cytoplasm extracellular vesicle cytosol outer dense plaque of desmosome membrane cell-cell junction focal adhesion cell-substrate junction adherens junction plasma membrane inner dense plaque of desmosome terminal web extracellular region cell junction brush border actin cytoskeleton zonula adherens membrane raft fascia adherens costamere cytoskeleton extracellular exosome podosome secretory granule lumen specific granule lumen ficolin-1-rich granule lumen sarcolemma Biological process regulation of cell migration muscle contraction adherens junction assembly epithelial cell-cell adhesion platelet degranulation morphogenesis of an epithelium cell adhesion negative regulation of cell migration protein localization to cell surface axon extension cell-matrix adhesion platelet aggregation apical junction assembly lamellipodium assembly neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7414 22330 Ensembl ENSG00000035403 ENSMUSG00000021823 UniProt P18206 Q64727 RefSeq (mRNA) NM_003373 NM_014000 NM_009502 RefSeq (protein) NP_003364 NP_054706 NP_033528 Location (UCSC) Chr 10: 74 – 74.12 Mb Chr 14: 20.98 – 21.08 Mb PubMed search [3] [4]
Wikidata
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In mammalian cells, vinculin is a membrane-cytoskeletal protein in focal adhesion plaques that is involved in linkage of integrin adhesion molecules to the actin cytoskeleton. Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane.

Discovered independently by Benny Geiger^[5] and Keith Burridge,^[6] its sequence is 20%–30% similar to α-catenin, which serves a similar function.

Binding alternately to talin or α-actinin, vinculin's shape and, as a consequence, its binding properties are changed. The vinculin gene occurs as a single copy and what appears to be no close relative to take over functions in its absence. Its splice variant metavinculin (see below) also needs vinculin to heterodimerize and work in a dependent fashion.