Von Willebrand factor

VWF
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AO3, 1ATZ, 1AUQ, 1FE8, 1FNS, 1IJB, 1IJK, 1M10, 1OAK, 1U0N, 2ADF, 3GXB, 3HXO, 3HXQ, 3PPV, 3PPW, 3PPX, 3PPY, 3ZQK, 4DMU, 1UEX, 2MHP, 2MHQ, 4C29, 4C2A, 4C2B, 4NT5, 5BV8
Identifiers
Aliases	VWF, F8VWD, von Willebrand factor
External IDs	OMIM: 613160; MGI: 98941; HomoloGene: 466; GeneCards: VWF; OMA:VWF - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.31 Start 5,948,877 bp[1] End 6,124,770 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 F3|6 59.32 cM Start 125,523,737 bp[2] End 125,663,642 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in urethra tendon of biceps brachii apex of heart right lung upper lobe of left lung pericardium left ventricle subcutaneous adipose tissue right auricle lower lobe of lung Top expressed in right lung lobe external carotid artery internal carotid artery belly cord tunica media of zone of aorta blood carotid body pineal gland tunica adventitia of aorta sciatic nerve More reference expression data BioGPS n/a
Gene ontology Molecular function chaperone binding protein homodimerization activity collagen binding protein N-terminus binding immunoglobulin binding protease binding integrin binding identical protein binding protein binding extracellular matrix structural constituent Cellular component platelet alpha granule Weibel-Palade body extracellular region endoplasmic reticulum extracellular exosome platelet alpha granule lumen extracellular matrix collagen-containing extracellular matrix Biological process hemostasis blood coagulation, intrinsic pathway platelet degranulation extracellular matrix organization blood coagulation cell-substrate adhesion cell adhesion response to wounding protein homooligomerization platelet activation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7450 22371 Ensembl ENSG00000110799 ENSMUSG00000001930 UniProt P04275 Q8CIZ8 RefSeq (mRNA) NM_000552 NM_011708 RefSeq (protein) NP_000543 NP_035838 Location (UCSC) Chr 12: 5.95 – 6.12 Mb Chr 6: 125.52 – 125.66 Mb PubMed search [3] [4]
Wikidata
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Von Willebrand factor (VWF) (German: [fɔn ˈvɪləbʁant]) is a blood glycoprotein that promotes hemostasis, specifically, platelet adhesion. It is deficient and/or defective in von Willebrand disease and is involved in many other diseases, including thrombotic thrombocytopenic purpura, Heyde's syndrome, and possibly hemolytic–uremic syndrome.^[5] Increased plasma levels in many cardiovascular, neoplastic, metabolic (e.g. diabetes), and connective tissue diseases are presumed to arise from adverse changes to the endothelium, and may predict an increased risk of thrombosis.^[6]