XPB

ERCC3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4ERN, 5IY9, 5IVW, 5IY7, 5IY8, 5IY6
Identifiers
Aliases	ERCC3, excision repair cross-complementation group 3, BTF2, GTF2H, RAD25, TFIIH, XPB, TTD2, ERCC excision repair 3, TFIIH core complex helicase subunit, Ssl2
External IDs	OMIM: 133510; MGI: 95414; HomoloGene: 96; GeneCards: ERCC3; OMA:ERCC3 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	127,294,166 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	32,403,204 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; right hemisphere of cerebellum; ; right uterine tube; ; gastric mucosa; ; gonad; ; granulocyte; ; ganglionic eminence; ; body of uterus; ; anterior pituitary; ; canal of the cervix;
	Top expressed in
	spermatid; ; renal corpuscle; ; granulocyte; ; endothelial cell of lymphatic vessel; ; ventricular zone; ; epiblast; ; tail of embryo; ; medullary collecting duct; ; lumbar spinal ganglion; ; yolk sac;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein C-terminus binding; nucleotide binding; DNA helicase activity; protein kinase activity; hydrolase activity; ATP-dependent activity, acting on DNA; protein N-terminus binding; 3'-5' DNA helicase activity; ATP binding; damaged DNA binding; DNA binding; transcription factor binding; protein binding; helicase activity; RNA polymerase II CTD heptapeptide repeat kinase activity; ATPase activity; DNA translocase activity;
Cellular component	transcription factor TFIIH core complex; nucleus; nucleoplasm; transcription factor TFIIH holo complex; transcription factor TFIID complex; nucleotide-excision repair factor 3 complex; transcription preinitiation complex;
Biological process	response to hypoxia; termination of RNA polymerase I transcription; embryonic organ development; transcription, DNA-templated; response to UV; 7-methylguanosine mRNA capping; nucleotide-excision repair, DNA incision; regulation of mitotic cell cycle phase transition; apoptotic process; positive regulation of apoptotic process; protein phosphorylation; hair cell differentiation; response to oxidative stress; UV protection; cellular response to DNA damage stimulus; transcription initiation from RNA polymerase II promoter; global genome nucleotide-excision repair; protein localization; transcription elongation from RNA polymerase II promoter; regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; DNA topological change; transcription initiation from RNA polymerase I promoter; transcription by RNA polymerase II; transcription-coupled nucleotide-excision repair; nucleotide-excision repair; nucleotide-excision repair, preincision complex stabilization; DNA repair; viral process; nucleotide-excision repair, preincision complex assembly; nucleotide-excision repair, DNA incision, 5'-to lesion; nucleotide-excision repair, DNA duplex unwinding; regulation of mitotic recombination; promoter clearance from RNA polymerase II promoter; transcription open complex formation at RNA polymerase II promoter; regulation of transposition, RNA-mediated; phosphorylation of RNA polymerase II C-terminal domain; regulation of RNA polymerase II regulatory region sequence-specific DNA binding; nucleotide-excision repair, DNA incision, 3'-to lesion; transcription elongation from RNA polymerase I promoter;
	Sources:Amigo / QuickGO
Orthologs
	2071
	13872
	ENSG00000163161
	ENSMUSG00000024382
	P19447
	P49135
	NM_000122; NM_001303416; NM_001303418
	NM_133658
	NP_000113; NP_001290345; NP_001290347
	NP_598419
	Wikidata
View/Edit Human	View/Edit Mouse

XPB (xeroderma pigmentosum type B) is an ATP-dependent DNA helicase in humans that is a part of the TFIIH transcription factor complex.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163161 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024382 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163161 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024382 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

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