Young blood transfusion

Young blood transfusion refers to transfusing blood specifically from a young person into an older one with the intention of creating a health benefit.^[1] The efficacy and safety of young blood transfusions for anti-aging purposes remain a subject of debate in the scientific community, with limited clinical evidence in humans.^[1]^[2]^[3] There are also concerns of harm.^[3] While some preclinical studies on animals suggest potential benefits, there is a lack of robust clinical evidence to support its use in humans.^[4]^[5]^[6]^[7]^[8]^[9] The U.S. Food and Drug Administration, in 2019, cautioned "consumers against receiving young donor plasma infusions" stating that they are an "unproven treatment".^[3]

^ ^a ^b Novella S (3 August 2016). "Parabiosis – The Next Snakeoil". Science-Based Medicine.
^ Robbins R (March 2, 2018). "Young-Blood Transfusions Are on the Menu at Society Gala". Scientific American. Retrieved 26 May 2018.
^ ^a ^b ^c Cite error: The named reference FDA2019 was invoked but never defined (see the help page).
^ Conboy IM, Conboy MJ, Wagers AJ, Girma ER, Weissman IL, Rando TA (February 2005). "Rejuvenation of aged progenitor cells by exposure to a young systemic environment". Nature. 433 (7027): 760–764. Bibcode:2005Natur.433..760C. doi:10.1038/nature03260. PMID 15716955.
^ Sinha M, Jang YC, Oh J, Khong D, Wu EY, Manohar R, et al. (May 2014). "Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle". Science. 344 (6184): 649–652. Bibcode:2014Sci...344..649S. doi:10.1126/science.1251152. PMC 4104429. PMID 24797481.
^ Villeda SA, Plambeck KE, Middeldorp J, Castellano JM, Mosher KI, Luo J, et al. (June 2014). "Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice". Nature Medicine. 20 (6): 659–663. doi:10.1038/nm.3569. PMC 4224436. PMID 24793238.
^ Katsimpardi L, Litterman NK, Schein PA, Miller CM, Loffredo FS, Wojtkiewicz GR, et al. (May 2014). "Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors". Science. 344 (6184): 630–634. Bibcode:2014Sci...344..630K. doi:10.1126/science.1251141. PMC 4123747. PMID 24797482.
^ Mccay CM, Pope F, Lunsford W, Sperling G, Sambhavaphol P (1957). "Parabiosis between old and young rats". Gerontologia. 1 (1): 7–17. doi:10.1159/000210677. PMID 13405201.
^ Horvath S, Singh K, Raj K, Khairnar SI, Sanghavi A, Shrivastava A, et al. (February 2024). "Reversal of biological age in multiple rat organs by young porcine plasma fraction". GeroScience. 46 (1): 367–394. doi:10.1007/s11357-023-00980-6. PMC 10828479. PMID 37875652.

[sbm-1] Novella S (3 August 2016). "Parabiosis – The Next Snakeoil". Science-Based Medicine.

[sciam-2] Robbins R (March 2, 2018). "Young-Blood Transfusions Are on the Menu at Society Gala". Scientific American. Retrieved 26 May 2018.

[FDA2019-3] Cite error: The named reference FDA2019 was invoked but never defined (see the help page).

[4] Conboy IM, Conboy MJ, Wagers AJ, Girma ER, Weissman IL, Rando TA (February 2005). "Rejuvenation of aged progenitor cells by exposure to a young systemic environment". Nature. 433 (7027): 760–764. Bibcode:2005Natur.433..760C. doi:10.1038/nature03260. PMID 15716955.

[5] Sinha M, Jang YC, Oh J, Khong D, Wu EY, Manohar R, et al. (May 2014). "Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle". Science. 344 (6184): 649–652. Bibcode:2014Sci...344..649S. doi:10.1126/science.1251152. PMC 4104429. PMID 24797481.

[6] Villeda SA, Plambeck KE, Middeldorp J, Castellano JM, Mosher KI, Luo J, et al. (June 2014). "Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice". Nature Medicine. 20 (6): 659–663. doi:10.1038/nm.3569. PMC 4224436. PMID 24793238.

[7] Katsimpardi L, Litterman NK, Schein PA, Miller CM, Loffredo FS, Wojtkiewicz GR, et al. (May 2014). "Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors". Science. 344 (6184): 630–634. Bibcode:2014Sci...344..630K. doi:10.1126/science.1251141. PMC 4123747. PMID 24797482.

[8] Mccay CM, Pope F, Lunsford W, Sperling G, Sambhavaphol P (1957). "Parabiosis between old and young rats". Gerontologia. 1 (1): 7–17. doi:10.1159/000210677. PMID 13405201.

[9] Horvath S, Singh K, Raj K, Khairnar SI, Sanghavi A, Shrivastava A, et al. (February 2024). "Reversal of biological age in multiple rat organs by young porcine plasma fraction". GeroScience. 46 (1): 367–394. doi:10.1007/s11357-023-00980-6. PMC 10828479. PMID 37875652.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]