Apolipoproteinum E | |||||
---|---|---|---|---|---|
Alia nomina | ApoE, APOE, APO-E, LDLCQ5, LPG, ApoE4 | ||||
Locus geni (homo) | |||||
Chromosoma | 19 (humanum) | ||||
Locus | 19q13.32 (homo) | ||||
Fontes externae | OMIM: 107741 |
Apolipoproteinum E (ApoE abbreviatum) est proteinorum classis metabolismi lipidorum. Lipoproteinum ApoE e lipidis aminoacidis formatum est.
Nomen geni eius, quod in hominibus in chromosomate 19 invenitur, APOE est. Polymorphismi ApoE noti sunt: adhuc variantia genorum allela tria (et tres isoformae), APOE-ε2 (ApoE2), -ε3 (ApoE3), -ε4 (ApoE4), et alia investigata sunt. Omnibus 299 aminoacidorum sunt[1].
ApoE transportator imprimis triglyceridorum et minus cholesteroli momentum maximum habet, velut in diversis morbis ut morbo Alzheimeriano, dysbetalipoproteinaemia familiari (typus III hyperlipoproteinaemiarum)[2], lipoproteinis glomerulopathia (LPG).
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