Back صميم البروتين الشحمي E Arabic Apolipoprotein E BS Apolipoproteïna E Catalan APOE Welsh Apolipoprotein E German Apolipoprotein E English Apolipoproteína E Spanish آپولیپوپروتئین ایی Persian Apolipoproteiini E Finnish Apolipoprotéine E French
| Apolipoproteinum E | |||||
|---|---|---|---|---|---|
| Alia nomina | ApoE, APOE, APO-E, LDLCQ5, LPG, ApoE4 | ||||
| Locus geni (homo) | |||||
 | |||||
| Chromosoma | 19 (humanum) | ||||
| Locus | 19q13.32 (homo) | ||||
 | |||||
| Fontes externae | OMIM: 107741 | ||||
Apolipoproteinum E (ApoE abbreviatum) est proteinorum classis metabolismi lipidorum. Lipoproteinum ApoE e lipidis aminoacidis formatum est.
Nomen geni eius, quod in hominibus in chromosomate 19 invenitur, APOE est. Polymorphismi ApoE noti sunt: adhuc variantia genorum allela tria (et tres isoformae), APOE-ε2 (ApoE2), -ε3 (ApoE3), -ε4 (ApoE4), et alia investigata sunt. Omnibus 299 aminoacidorum sunt[1].
ApoE transportator imprimis triglyceridorum et minus cholesteroli momentum maximum habet, velut in diversis morbis ut morbo Alzheimeriano, dysbetalipoproteinaemia familiari (typus III hyperlipoproteinaemiarum)[2], lipoproteinis glomerulopathia (LPG).
- ↑ Rall S. C. Jr., Weisgraber K. H., Mahley R. W. (1982). "Human apolipoprotein E. The complete amino acid sequence". The journal of biological chemistry 257 (8): 4171-8
- ↑ Smelt A. H., de Beer F. (2004). "Apolipoprotein E and familial dysbetalipoproteinemia: clinical, biochemical, and genetic aspects". Seminars in vascular medicine 4 (3): 249-57
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