Insulinski receptor

insulin receptor
Identifikatori
Alijasi
Spoljašnji ID	GeneCards: [1]
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	More reference expression data
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	Wikidata
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Insulinski receptor (IR) je transmembranski receptor koji aktiviraju insulin, IGF-I, IGF-II, i koji pripada velikoj klasi receptorskih tirozinskih kinaza.^[1] U pogledu metabolizma, insulinskih receptor ima ključnu ulogu u regulaciji glukozne homeostaze, funkcionalnog procesa koji pod degenerivnim okolnostima može da dovede do niza kliničkih manifestacija, uključujući dijabetes i kancer.^[2]^[3] Biohemijski, insulinski receptor je kodiran jednim genom INSR, iz koga se alternativnim splajsovanjem tokom transkripcije formiraju bilo IR-A ili IR-B izoforma.^[4] Dalje posttranslacione izmene ovih izoformi dovode do formiranja proteolitički skraćenih α i β podjedinica, koje nakon kombinovanja imaju sposobnost formiranja homo ili hetero-dimera, čime nastaje ≈320 kDa disulfidno vezani transmembranski insulinski receptor.^[4]

^ Ward CW, Lawrence MC (2009). „Ligand-induced activation of the insulin receptor: a multi-step process involving structural changes in both the ligand and the receptor”. BioEssays. 31 (4): 422—34. PMID 19274663. doi:10.1002/bies.200800210.
^ Ebina Y, Ellis L (1985). „The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling.”. Cell. 40 (4): 747—58. PMID 2859121. doi:10.1016/0092-8674(85)90334-4.
^ Malaguarnera R, Belfiore A (2012). „Proinsulin Binds with High Affinity the Insulin Receptor Isoform A and Predominantly Activates the Mitogenic Pathway.”. Endocrinology. Epub (5): 2152—63. PMID 22355074. doi:10.1210/en.2011-1843.
^ ^а ^б Belfiore A, Frasca F (2009). „Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease.”. Endocr Rev. 30 (6): 586—623. PMID 19752219. doi:10.1210/er.2008-0047.

[pmid19274663-1] Ward CW, Lawrence MC (2009). „Ligand-induced activation of the insulin receptor: a multi-step process involving structural changes in both the ligand and the receptor”. BioEssays. 31 (4): 422—34. PMID 19274663. doi:10.1002/bies.200800210.

[pmid2859121-2] Ebina Y, Ellis L (1985). „The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling.”. Cell. 40 (4): 747—58. PMID 2859121. doi:10.1016/0092-8674(85)90334-4.

[pmid22355074-3] Malaguarnera R, Belfiore A (2012). „Proinsulin Binds with High Affinity the Insulin Receptor Isoform A and Predominantly Activates the Mitogenic Pathway.”. Endocrinology. Epub (5): 2152—63. PMID 22355074. doi:10.1210/en.2011-1843.

[pmid19752219-4] а ^б Belfiore A, Frasca F (2009). „Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease.”. Endocr Rev. 30 (6): 586—623. PMID 19752219. doi:10.1210/er.2008-0047.

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