Adenosine A1 receptor

ADORA1
Identifiers
Aliases	ADORA1, RDC7, adenosine A1 receptor
External IDs	OMIM: 102775 MGI: 99401 HomoloGene: 20165 GeneCards: ADORA1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	203,167,405 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	134,163,169 bp
RNA expression pattern
	Top expressed in
	inferior ganglion of vagus nerve; ; prefrontal cortex; ; Brodmann area 10; ; putamen; ; pons; ; amygdala; ; ventral tegmental area; ; vena cava; ; middle frontal gyrus; ; nucleus accumbens;
	Top expressed in
	pontine nuclei; ; medial geniculate nucleus; ; cerebellar cortex; ; cerebellar vermis; ; subiculum; ; facial motor nucleus; ; superior frontal gyrus; ; barrel cortex; ; anterior horn of spinal cord; ; medial dorsal nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	G-protein beta/gamma-subunit complex binding; G protein-coupled adenosine receptor activity; G protein-coupled receptor activity; signal transducer activity; purine nucleoside binding; protein binding; protein heterodimerization activity; phospholipase C activity; heterotrimeric G-protein binding; G protein-coupled receptor binding; heat shock protein binding; neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration;
Cellular component	integral component of membrane; cell body; postsynaptic membrane; membrane; postsynaptic density; dendritic spine; synapse; integral component of plasma membrane; presynaptic active zone; terminal bouton; neuronal cell body; dendrite; basolateral plasma membrane; endoplasmic reticulum; axolemma; asymmetric synapse; presynaptic membrane; endomembrane system; plasma membrane; integral component of postsynaptic membrane; integral component of presynaptic membrane; calyx of Held;
Biological process	negative regulation of circadian sleep/wake cycle, non-REM sleep; positive regulation of nucleoside transport; positive regulation of epidermal growth factor-activated receptor activity; G protein-coupled adenosine receptor signaling pathway; negative regulation of neurotrophin production; negative regulation of glutamate secretion; response to hypoxia; negative regulation of acute inflammatory response; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; regulation of sensory perception of pain; cognition; positive regulation of protein dephosphorylation; negative regulation of blood pressure; negative regulation of heart contraction; protein targeting to membrane; positive regulation of potassium ion transport; regulation of glomerular filtration; cell-cell signaling; positive regulation of peptide secretion; negative regulation of apoptotic process; nervous system development; detection of temperature stimulus involved in sensory perception of pain; regulation of respiratory gaseous exchange by nervous system process; lipid catabolic process; negative regulation of circadian sleep/wake cycle, sleep; positive regulation of blood pressure; negative regulation of synaptic transmission, GABAergic; negative regulation of renal sodium excretion; excitatory postsynaptic potential; phagocytosis; relaxation of vascular associated smooth muscle; apoptotic signaling pathway; regulation of cardiac muscle contraction; negative regulation of long-term synaptic depression; temperature homeostasis; inflammatory response; negative regulation of mucus secretion; negative regulation of hormone secretion; negative regulation of lipid catabolic process; negative regulation of inflammatory response; negative regulation of leukocyte migration; negative regulation of synaptic transmission, glutamatergic; signal transduction; negative regulation of cell population proliferation; negative regulation of cardiac muscle contraction; G protein-coupled receptor signaling pathway; positive regulation of systemic arterial blood pressure; negative regulation of systemic arterial blood pressure; positive regulation of lipid catabolic process; fatty acid homeostasis; triglyceride homeostasis; negative regulation of long-term synaptic potentiation; positive regulation of neuron death; regulation of cardiac muscle cell contraction; regulation of presynaptic cytosolic calcium ion concentration;
	Sources:Amigo / QuickGO
Orthologs
	134
	11539
	ENSG00000163485
	ENSMUSG00000042429
	P30542
	Q60612
	NM_000674; NM_001048230; NM_001365065; NM_001365066
NM_001008533; NM_001039510; NM_009629; NM_001282945; NM_001291928;
	NM_001291930
	NP_000665; NP_001041695; NP_001351994; NP_001351995
	NP_001008533; NP_001034599; NP_001269874; NP_001278857; NP_001278859
	Wikidata
View/Edit Human	View/Edit Mouse

The adenosine A₁ receptor (A1AR) ^[5] is one member of the adenosine receptor group of G protein-coupled receptors with adenosine as endogenous ligand.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163485 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042429 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Townsend-Nicholson A, Baker E, Schofield PR, Sutherland GR (March 1995). "Localization of the adenosine A1 receptor subtype gene (ADORA1) to chromosome 1q32.1". Genomics. 26 (2): 423–425. doi:10.1016/0888-7543(95)80236-F. PMID 7601478.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163485 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042429 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7601478-5] Townsend-Nicholson A, Baker E, Schofield PR, Sutherland GR (March 1995). "Localization of the adenosine A1 receptor subtype gene (ADORA1) to chromosome 1q32.1". Genomics. 26 (2): 423–425. doi:10.1016/0888-7543(95)80236-F. PMID 7601478.

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