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CCL4

CCL4
Нинди таксонда бар H. sapiens[d][1]
Кодлаучы ген CCL4[d][1] һәм CCL4L1[1]
Молекуляр функция cytokine activity[d][2][3], CCR5 chemokine receptor binding[d][4][5], CCR1 chemokine receptor binding[d][6], связывание с белками плазмы[d][7], связывание похожих белков[d][8], chemokine activity[d][9][3][10] һәм CCR chemokine receptor binding[d][10]
Күзәнәк компоненты күзәнәк тышындагы өлкә[d][3][3][3] һәм күзәнәк тышындагы мохит[d][11][3][10]
Биологик процесс positive regulation of calcium-mediated signaling[d][4], monocyte chemotaxis[d][10], positive regulation of natural killer cell chemotaxis[d][6], chemokine-mediated signaling pathway[d][10], cellular response to tumor necrosis factor[d][10], передача сигнала между клетками[d][11], response to virus[d][12], neutrophil chemotaxis[d][10], хемотаксис[d][3], establishment or maintenance of cell polarity[d][13], positive regulation of GTPase activity[d][10], агрегация клеток[d][9], cellular response to interleukin-1[d][10], иммун җавап[d][9][3], positive regulation of ERK1 and ERK2 cascade[d][10], cellular response to interferon-gamma[d][10], response to toxic substance[d][14], передача сигнала[d][9][15], positive regulation of calcium ion transport[d][16], воспалительная реакция[d][11][3][10], regulation of signaling receptor activity[d][3], G protein-coupled receptor signaling pathway[d][3][10], cytokine-mediated signaling pathway[d][3], eosinophil chemotaxis[d][10] һәм lymphocyte chemotaxis[d][10]
Изображение Gene Atlas

CCL4 (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[17][18]

  1. ↑ 1,0 1,1 1,2 UniProt
  2. ↑ Lipes M. A., M Napolitano, Jeang K. T. et al. Identification, cloning, and characterization of an immune activation gene // Proc. Natl. Acad. Sci. U.S.A. / M. R. Berenbaum — [Washington, etc.], USA: National Academy of Sciences [etc.], 1988. — ISSN 0027-8424; 1091-6490 — doi:10.1073/PNAS.85.24.9704 — PMID:2462251
  3. ↑ 3,00 3,01 3,02 3,03 3,04 3,05 3,06 3,07 3,08 3,09 3,10 3,11 GOA
  4. ↑ 4,0 4,1 N Reiling Lipopolysaccharide inhibits HIV-1 infection of monocyte- derived macrophages through direct and sustained down-regulation of CC chemokine receptor 5 // J. Immunol. — Baltimore: 2000. — ISSN 0022-1767; 1550-6606 — doi:10.4049/JIMMUNOL.164.5.2592 — PMID:10679098
  5. ↑ Lee B. Extracellular cysteines of CCR5 are required for chemokine binding, but dispensable for HIV-1 coreceptor activity // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1999. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.274.27.18902 — PMID:10383387
  6. ↑ 6,0 6,1 A Ben-Baruch, L Xu, Young P. R. et al. Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3 // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1995. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.270.38.22123 — PMID:7545673
  7. ↑ Dricot A., Barabási A., Tavernier J. et al. A proteome-scale map of the human interactome network // Cell — Cell Press, Elsevier, 2014. — ISSN 0092-8674; 1097-4172 — doi:10.1016/J.CELL.2014.10.050 — PMID:25416956
  8. ↑ Lenz M., Koenen R. R., Tang W. et al. Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme // EMBO J. — NPG, 2010. — ISSN 0261-4189; 1460-2075 — doi:10.1038/EMBOJ.2010.256 — PMID:20959807
  9. ↑ 9,0 9,1 9,2 9,3 A Brill Induction of interactions between CD44 and hyaluronic acid by a short exposure of human T cells to diverse pro-inflammatory mediators // Immunology — Wiley-Blackwell, 2000. — ISSN 0019-2805; 1365-2567 — doi:10.1046/J.1365-2567.2000.00059.X — PMID:10929056
  10. ↑ 10,00 10,01 10,02 10,03 10,04 10,05 10,06 10,07 10,08 10,09 10,10 10,11 10,12 10,13 10,14 Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform. — OUP, 2011. — ISSN 1467-5463; 1477-4054 — doi:10.1093/BIB/BBR042 — PMID:21873635
  11. ↑ 11,0 11,1 11,2 Zipfel P. F., J Balke, Irving S. G. et al. Mitogenic activation of human T cells induces two closely related genes which share structural similarities with a new family of secreted factors // J. Immunol. — Baltimore: 1989. — ISSN 0022-1767; 1550-6606 — PMID:2521882
  12. ↑ Rabin R. L. CXCR4 and CCR5 on human thymocytes: biological function and role in HIV-1 infection // J. Immunol. — Baltimore: 1998. — ISSN 0022-1767; 1550-6606 — PMID:9743377
  13. ↑ M. A. del Pozo Roles of chemokines and receptor polarization in NK-target cell interactions // J. Immunol. — Baltimore: 1998. — ISSN 0022-1767; 1550-6606 — PMID:9759849
  14. ↑ Kanki P. J., Essex M. E. In vitro correlates of HIV-2-mediated HIV-1 protection // Proc. Natl. Acad. Sci. U.S.A. / M. R. Berenbaum — [Washington, etc.], USA: National Academy of Sciences [etc.], 2000. — ISSN 0027-8424; 1091-6490 — doi:10.1073/PNAS.97.12.6797 — PMID:10841574
  15. ↑ Fauci A. S., M Dybul, AS F. et al. Dendritic cells express multiple chemokine receptors used as coreceptors for HIV entry // J. Immunol. — Baltimore: 1998. — ISSN 0022-1767; 1550-6606 — PMID:9558100
  16. ↑ C Combadiere, Ahuja S. K., Tiffany H. L. et al. Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES // J. Leukoc. Biol. / L. Montaner — Wiley-Blackwell, 1996. — ISSN 0741-5400; 1938-3673 — doi:10.1002/JLB.60.1.147 — PMID:8699119
  17. ↑ HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланды. 18 сентябрь, 2017 тикшерелгән.
  18. ↑ UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

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