Dicer

DICER1
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 2EB1, 4NGB, 4NGC, 4NGD, 4NGF, 4NGG, 4NH3, 4NH5, 4NH6, 4NHA, 4WYQ
Identifikatori
Aliasi	DICER1
Vanjski ID-jevi	OMIM: 606241 MGI: 2177178 HomoloGene: 13251 GeneCards: DICER1
Lokacija gena (čovjek) Hrom. Hromosom 14 (čovjek)[1] Bend 14q32.13 Početak 95,086,228 bp[1] Kraj 95,158,010 bp[1]
Lokacija gena (miš) Hrom. Hromosom 12 (miš)[2] Bend 12 E|12 54.83 cM Početak 104,654,001 bp[2] Kraj 104,718,211 bp[2]
Ontologija gena Molekularna funkcija • nucleotide binding • GO:0008026 helicase activity • protein domain specific binding • pre-miRNA binding • vezivanje iona metala • endoribonuclease activity • endoribonuclease activity, producing 5'-phosphomonoesters • GO:0001948, GO:0016582 vezivanje za proteine • siRNA binding • vezivanje sa RNK • nuclease activity • double-stranded RNA binding • endonuclease activity • hydrolase activity • ATP binding • ribonuclease III activity • vezivanje sa DNK • deoxyribonuclease I activity Ćelijska komponenta • citoplazma • citosol • RNK-inducirani kompleks utišavanja • growth cone • ARC complex • RISC-loading complex • Akson • dendrit • jedro • endoplasmic reticulum-Golgi intermediate compartment • Egzosom Biološki proces • neuron projection morphogenesis • GO:0033168, GO:0036404, GO:1902360 RNA processing • GO:1901227 negative regulation of transcription by RNA polymerase II • peripheral nervous system myelin formation • pre-miRNA processing • positive regulation of myelination • nerve development • RNA phosphodiester bond hydrolysis, endonucleolytic • positive regulation of Schwann cell differentiation • negative regulation of Schwann cell proliferation • production of miRNAs involved in gene silencing by miRNA • GO:0061715 miRNA metabolic process • GO:0070919 production of siRNA involved in RNA interference • Utišavanje gena • apoptotic DNA fragmentation • negative regulation of tumor necrosis factor production • NIK/NF-kappaB signaling • negative regulation of gene expression • tube formation Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	23405	192119
Ensembl	ENSG00000100697	ENSMUSG00000041415
UniProt	Q9UPY3	Q8R418
RefSeq (mRNK)	NM_001195573 NM_001271282 NM_001291628 NM_030621 NM_177438	NM_148948
RefSeq (bjelančevina)	NP_001182502 NP_001258211 NP_001278557 NP_085124 NP_803187	NP_683750
Lokacija (UCSC)	Chr 14: 95.09 – 95.16 Mb	Chr 12: 104.65 – 104.72 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Dicer, znan i kao endoribonukleaza Dicer ili helikaza s RNKaznim motivom, jest enzim koji je kod ljudi kodiran genom DICER1 sa hromosoma 14. Budući da je dio porodice RNaza III, Dicer cijepa dvolančanu RNK (dsRNK) , pre-mikroRNK (pre-miRNK) u kratke dvolančane fragmente RNK zvane mala interferirajuća RNK odnosno i mikroRNK, respektivno. Ovi fragmenti su dugi otprilike 20-25 baznih parova sa dvobaznim prevjesom na 3' krajevima. Dicer olakšava aktivaciju RNK-induciranog kompleksa utišavanja (RISC), koji je neophodan za RNK- interferenciju. RISC ima katalitsku komponentu Argonaut, koja je endonukleaza sposobna da razgradi iRNK (mRNK).

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000100697 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000041415 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.