E2F1

E2F1
Structures disponibles
PDB	Recherche d'orthologue: PDBe RCSB
Identifiants PDB
	1H24, 1O9K, 2AZE
Identifiants
Aliases	E2F1
IDs externes	OMIM: 189971 MGI: 101941 HomoloGene: 3828 GeneCards: E2F1
Position du gène (Homme)
Chr.	Chromosome 20 humain
Fin	33,686,385 bp
Position du gène (Souris)
Chr.	Chromosome 2 (souris)
Fin	154,411,812 bp
Expression génique
	Fortement exprimé dans
	éminence ganglionnaire; ; secondary oocyte; ; ventricular zone; ; gonade; ; mucosa of transverse colon; ; stromal cell of endometrium; ; cortex préfrontal; ; testicule; ; moelle osseuse; ; putamen;
	Fortement exprimé dans
	zygote; ; secondary oocyte; ; Ectoderme; ; otic vesicle; ; otic placode; ; primary oocyte; ; fetal liver hematopoietic progenitor cell; ; ventricular zone; ; saccule; ; gastrula;
	Plus de données d'expression de référence
	; ;
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	liaison ADN; DNA-binding transcription factor activity; transcription factor binding; liaison protéique; protein dimerization activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; protein kinase binding; cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific;
Composant cellulaire	cytoplasme; transcription regulator complex; Rb-E2F complex; noyau; mitochondrie; nucléoplasme; centrosome; complexe macromoléculaire; RNA polymerase II transcription regulator complex;
Processus biologique	cellular response to nerve growth factor stimulus; negative regulation of fat cell differentiation; regulation of transcription, DNA-templated; lens fiber cell apoptotic process; negative regulation of transcription involved in G1/S transition of mitotic cell cycle; positive regulation of fibroblast proliferation; negative regulation of DNA binding; negative regulation of fat cell proliferation; DNA damage checkpoint signaling; cellular response to xenobiotic stimulus; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; régulation du cycle cellulaire; régulation positive de la transcription dépendante de l'ADN; regulation of G1/S transition of mitotic cell cycle; mRNA stabilization; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; positive regulation of gene expression; cellular response to fatty acid; Anoïkose; spermatogenèse; intrinsic apoptotic signaling pathway in response to DNA damage; intrinsic apoptotic signaling pathway by p53 class mediator; cycle cellulaire; forebrain development; negative regulation of transcription, DNA-templated; cellular response to hypoxia; positive regulation of transcription by RNA polymerase II; apoptose; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of transcription involved in G1/S transition of mitotic cell cycle; positive regulation of apoptotic process; negative regulation of G0 to G1 transition; positive regulation of glial cell proliferation;
	Sources:Amigo / QuickGO
Orthologues
	1869
	13555
	ENSG00000101412
	ENSMUSG00000027490
	Q01094
	Q61501
	NM_005225
	NM_007891; NM_001291105
	NP_005216
	NP_001278034; NP_031917
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

L'E2F1 est une protéine de la famille des E2Fs et jouant le rôle de facteur de transcription. Son gène est E2F1 situé sur le chromosome 20 humain.

↑ ^{a b et c} GRCh38: Ensembl release 89: ENSG00000101412 - Ensembl, May 2017
↑ ^{a b et c} GRCm38: Ensembl release 89: ENSMUSG00000027490 - Ensembl, May 2017
↑ « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[refGRCh38Ensembl-1] {a b et c} GRCh38: Ensembl release 89: ENSG00000101412 - Ensembl, May 2017

[refGRCm38Ensembl-2] {a b et c} GRCm38: Ensembl release 89: ENSMUSG00000027490 - Ensembl, May 2017

[3] « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[4] « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine

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