E2F2

E2F2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1N4M
Identifiers
Aliases	E2F2, E2F-2, E2F transcription factor 2
External IDs	OMIM: 600426; MGI: 1096341; HomoloGene: 48264; GeneCards: E2F2; OMA:E2F2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	23,531,233 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	135,923,368 bp
RNA expression pattern
	Top expressed in
	bone marrow; ; bone marrow cells; ; testicle; ; blood; ; gonad; ; mucosa of transverse colon; ; ganglionic eminence; ; ventricular zone; ; monocyte; ; granulocyte;
	Top expressed in
	blood; ; granulocyte; ; thymus; ; otic vesicle; ; human fetus; ; zygote; ; spleen; ; primary oocyte; ; internal carotid artery; ; hair follicle;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; transcription factor binding; protein binding; protein dimerization activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific;
Cellular component	nucleus; transcription regulator complex; nucleoplasm; RNA polymerase II transcription regulator complex;
Biological process	regulation of cell cycle; cell cycle; transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-templated; lens fiber cell apoptotic process; intrinsic apoptotic signaling pathway by p53 class mediator; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; negative regulation of sprouting angiogenesis; negative regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	1870
	242705
	ENSG00000007968; ENSG00000282899
	ENSMUSG00000018983
	Q14209
	P56931
	NM_004091
	NM_177733; NM_183301; NM_001305399
	NP_004082
	NP_001292328; NP_808401
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor E2F2 is a protein that in humans is encoded by the E2F2 gene.^[5]^[6]

^ ^a ^b ^c ENSG00000282899 GRCh38: Ensembl release 89: ENSG00000007968, ENSG00000282899 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018983 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ivey-Hoyle M, Conroy R, Huber HE, Goodhart PJ, Oliff A, Heimbrook DC (January 1994). "Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F". Mol Cell Biol. 13 (12): 7802–12. doi:10.1128/MCB.13.12.7802. PMC 364852. PMID 8246995.
^ Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K (January 1994). "The retinoblastoma protein binds to a family of E2F transcription factors". Mol Cell Biol. 13 (12): 7813–25. doi:10.1128/mcb.13.12.7813. PMC 364853. PMID 8246996.

[refGRCh38Ensembl-1] ENSG00000282899 GRCh38: Ensembl release 89: ENSG00000007968, ENSG00000282899 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000018983 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8246995-5] Ivey-Hoyle M, Conroy R, Huber HE, Goodhart PJ, Oliff A, Heimbrook DC (January 1994). "Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F". Mol Cell Biol. 13 (12): 7802–12. doi:10.1128/MCB.13.12.7802. PMC 364852. PMID 8246995.

[pmid8246996-6] Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K (January 1994). "The retinoblastoma protein binds to a family of E2F transcription factors". Mol Cell Biol. 13 (12): 7813–25. doi:10.1128/mcb.13.12.7813. PMC 364853. PMID 8246996.

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