Osteokalcin

BGLAP
Identifikatori
Aliasi	BGLAP
Vanjski ID-jevi	OMIM: 112260 MGI: 88155 HomoloGene: 104130 GeneCards: BGLAP
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	156,243,317 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	88,280,050 bp
Ontologija gena
Molekularna funkcija	• calcium ion binding; • structural molecule activity; • vezivanje iona metala; • hydroxyapatite binding; • structural constituent of bone;
Ćelijska komponenta	• citoplazma; • perikaryon; • rough endoplasmic reticulum; • Golđijev aparat; • projekcija ćelije; • endoplasmic reticulum lumen; • extracellular region; • dendrit; • Golgi lumen; • Vanćelijsko; • Vezikula;
Biološki proces	• skeletal system development; • bone mineralization; • response to vitamin D; • GO:1904578 response to organic cyclic compound; • ossification; • response to testosterone; • regulation of bone mineralization; • biomineral tissue development; • cellular response to growth factor stimulus; • response to mechanical stimulus; • GO:0010260 Starenje; • response to zinc ion; • response to glucocorticoid; • cellular response to vitamin D; • response to activity; • response to estrogen; • odontogenesis; • endoplasmic reticulum to Golgi vesicle-mediated transport; • response to gravity; • response to vitamin K; • response to hydroxyisoflavone; • Ćelijska adhezija; • response to nutrient levels; • regulation of osteoclast differentiation; • osteoblast differentiation; • response to inorganic substance; • osteoblast development; • response to ethanol; • regulation of bone resorption; • bone development; • regulation of cellular response to insulin stimulus;
	Izvori:Amigo / QuickGO
Ortolozi
	632
	12095
	ENSG00000242252
	ENSMUSG00000074489
	P02818
	P54615
	NM_199173
	NM_031368; NM_001305448; NM_001305449; NM_001305450
	NP_954642
	NP_001292377; NP_001292378; NP_001292379; NP_112736
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Osteokalcin – poznat i kao kostni protein sa gama-karboksiglutaminskom kiselinom (BGLAP) − je mali, 49-aminokiselinski^[5] nekolageni proteinski hormon, pronađen u kostima i dentinu, prvi put identificiran kao protein koji veže kalcij u kokošjoj kosti.^[6]

Budući da osteokalcin ima gla-domen, njegova sinteza zavisi od vitamina K. Kod ljudi, osteokalcin kodira gen BGLA.^[7]^[8] Njegovi receptori uključuju GPRC6A, GPR158 i, možda, treći receptor koji tek treba identificirati.^[9]^[10]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000242252 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000074489 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hauschka, P. V.; Carr, S. A.; Biemann, K. (1982). "Primary structure of monkey osteocalcin". Biochemistry. 21 (4): 638–42. doi:10.1021/bi00533a006. PMID 6978733.
^ Hauschka PV, Reid ML (august 1978). "Timed appearance of a calcium-binding protein containing gamma-carboxyglutamic acid in developing chick bone". Developmental Biology. 65 (2): 426–34. doi:10.1016/0012-1606(78)90038-6. PMID 680371.
^ Puchacz E, Lian JB, Stein GS, Wozney J, Huebner K, Croce C (maj 1989). "Chromosomal localization of the human osteocalcin gene". Endocrinology. 124 (5): 2648–50. doi:10.1210/endo-124-5-2648. PMID 2785029.
^ Cancela L, Hsieh CL, Francke U, Price PA (septembar 1990). "Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene". The Journal of Biological Chemistry. 265 (25): 15040–8. PMID 2394711.
^ Pi M, Wu Y, Quarles LD (juli 2011). "GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo". Journal of Bone and Mineral Research. 26 (7): 1680–3. doi:10.1002/jbmr.390. PMC 5079536. PMID 21425331.
^ Berger JM, Singh P, Khrimian L, Morgan DA, Chowdhury S, Arteaga-Solis E, et al. (septembar 2019). "Mediation of the Acute Stress Response by the Skeleton". Cell Metabolism. 30 (5): 890–902.e8. doi:10.1016/j.cmet.2019.08.012. PMC 6834912. PMID 31523009.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000242252 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000074489 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Hauschka, P. V.; Carr, S. A.; Biemann, K. (1982). "Primary structure of monkey osteocalcin". Biochemistry. 21 (4): 638–42. doi:10.1021/bi00533a006. PMID 6978733.

[6] Hauschka PV, Reid ML (august 1978). "Timed appearance of a calcium-binding protein containing gamma-carboxyglutamic acid in developing chick bone". Developmental Biology. 65 (2): 426–34. doi:10.1016/0012-1606(78)90038-6. PMID 680371.

[pmid2785029-7] Puchacz E, Lian JB, Stein GS, Wozney J, Huebner K, Croce C (maj 1989). "Chromosomal localization of the human osteocalcin gene". Endocrinology. 124 (5): 2648–50. doi:10.1210/endo-124-5-2648. PMID 2785029.

[pmid2394711-8] Cancela L, Hsieh CL, Francke U, Price PA (septembar 1990). "Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene". The Journal of Biological Chemistry. 265 (25): 15040–8. PMID 2394711.

[Pi_2011-9] Pi M, Wu Y, Quarles LD (juli 2011). "GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo". Journal of Bone and Mineral Research. 26 (7): 1680–3. doi:10.1002/jbmr.390. PMC 5079536. PMID 21425331.

[BergerSingh2019-10] Berger JM, Singh P, Khrimian L, Morgan DA, Chowdhury S, Arteaga-Solis E, et al. (septembar 2019). "Mediation of the Acute Stress Response by the Skeleton". Cell Metabolism. 30 (5): 890–902.e8. doi:10.1016/j.cmet.2019.08.012. PMC 6834912. PMID 31523009.

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