P16

CDKN2A
	Structure de la protéine CDKN2A. Basé sur l'identifiant PDB 1a5e.
Structures disponibles
PDB	Recherche d'orthologue: PDBe RCSB
Identifiants PDB
	2A5E, 1A5E, 1BI7, 1DC2,%%s1A5E, 1BI7, 1DC2, 2A5E
Identifiants
Aliases	CDKN2A
IDs externes	OMIM: 600160 MGI: 104738 HomoloGene: 55430 GeneCards: CDKN2A
Position du gène (Homme)
Chr.	Chromosome 9 humain
Fin	21,995,301 bp
Position du gène (Souris)
Chr.	Chromosome 4 (souris)
Fin	89,212,890 bp
Expression génique
	Fortement exprimé dans
	parotide; ; hypophyse; ; testicule; ; anté-hypophyse; ; noyau sous-thalamique; ; langue; ; aire tegmentale ventrale; ; mucosa of pharynx; ; superior surface of tongue; ; external globus pallidus;
	Fortement exprimé dans
	Vésicule vitelline; ; stroma of bone marrow; ; morula; ; embryon; ; glossopharyngeal ganglion; ; endothelial cell of lymphatic vessel; ; lumbar subsegment of spinal cord; ; calvaria; ; Ganglion géniculé; ; muscle de la cuisse;
	Plus de données d'expression de référence
	; ; ; ;
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	NF-kappaB binding; liaison protéique; cyclin-dependent protein serine/threonine kinase inhibitor activity; protein kinase binding; liaison ARN; liaison ADN; p53 binding; transcription factor binding; MDM2/MDM4 family protein binding; ubiquitin-protein transferase inhibitor activity; SUMO transferase activity; disordered domain specific binding; ubiquitin ligase inhibitor activity;
Composant cellulaire	cytoplasme; cytosol; senescence-associated heterochromatin focus; noyau; corps nucléaire; nucléoplasme; nucléole; mitochondrie; complexe macromoléculaire;
Processus biologique	positive regulation of smooth muscle cell apoptotic process; negative regulation of cyclin-dependent protein serine/threonine kinase activity; replicative senescence; phase G1; negative regulation of cell-matrix adhesion; sénescence cellulaire; negative regulation of cell growth; positive regulation of cellular senescence; positive regulation of macrophage apoptotic process; cycle cellulaire; Ras protein signal transduction; negative regulation of phosphorylation; negative regulation of transcription, DNA-templated; negative regulation of NF-kappaB transcription factor activity; negative regulation of cell population proliferation; G1/S transition of mitotic cell cycle; negative regulation of G1/S transition of mitotic cell cycle; apoptose; regulation of G2/M transition of mitotic cell cycle; regulation of transcription, DNA-templated; regulation of protein stability; negative regulation of immature T cell proliferation in thymus; regulation of protein export from nucleus; negative regulation of protein kinase activity; negative regulation of proteolysis involved in cellular protein catabolic process; protein K63-linked ubiquitination; positive regulation of signal transduction by p53 class mediator; division d'une cellule souche somatique; protein stabilization; protein polyubiquitination; positive regulation of protein sumoylation; transcription, DNA-templated; régulation positive de la transcription dépendante de l'ADN; mitophagie; apoptotic mitochondrial changes; regulation of protein targeting to mitochondrion; protein destabilization; negative regulation of ubiquitin-protein transferase activity; positive regulation of apoptotic process; rRNA processing; negative regulation of ubiquitin-dependent protein catabolic process; mitochondrial depolarization; positive regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of B cell proliferation; activation of cysteine-type endopeptidase activity involved in apoptotic process; regulation of apoptotic DNA fragmentation; positive regulation of transcription by RNA polymerase II; positive regulation of protein localization to nucleus; Sumoylation; positive regulation of gene expression; negative regulation of ubiquitin protein ligase activity; formation de fibrilles amyloïdes; negative regulation of protein neddylation;
	Sources:Amigo / QuickGO
Orthologues
	1029
	12578
	ENSG00000147889
	ENSMUSG00000044303
	P42771; Q8N726
	P51480; Q64364
NM_000077; NM_001195132; NM_058195; NM_058196; NM_058197;
	NM_001363763
	NM_001040654; NM_009877
NP_000068; NP_001182061; NP_478102; NP_478104; NP_001350692;
	NP_478102.2
	NP_001035744; NP_034007; NP_034007.1
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

Le p16 est une protéine suppresseuse de tumeur également connue sous le nom d'inhibiteur de kinase cycline-dépendante 2A (CDKN2A)^[5].

↑ ^{a b et c} GRCh38: Ensembl release 89: ENSG00000147889 - Ensembl, May 2017
↑ ^{a b et c} GRCm38: Ensembl release 89: ENSMUSG00000044303 - Ensembl, May 2017
↑ « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ Serrano M, Hannon GJ, Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature. 1993;366:704-7

[refGRCh38Ensembl-1] {a b et c} GRCh38: Ensembl release 89: ENSG00000147889 - Ensembl, May 2017

[refGRCm38Ensembl-2] {a b et c} GRCm38: Ensembl release 89: ENSMUSG00000044303 - Ensembl, May 2017

[3] « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[4] « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[5] Serrano M, Hannon GJ, Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature. 1993;366:704-7

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