Sterol

Gonan-3-ol, the simplest sterol

A sterol is any organic compound with a skeleton closely related to cholestan-3-ol. The simplest sterol is gonan-3-ol, which has a formula of C
17
H
28
O
, and is derived from that of gonane by replacement of a hydrogen atom on C3 position by a hydroxyl group. It is therefore an alcohol of gonane.[1][2][3]

More generally, any compounds that contain the gonane structure, additional functional groups, and/or modified ring systems derived from gonane are called steroids. Therefore, sterols are a subgroup of the steroids. They occur naturally in most eukaryotes, including plants, animals, and fungi, and can also be produced by some bacteria (however likely with different functions). [4][5] The most familiar type of animal sterol is cholesterol, which is vital to the structure of the cell membrane, and functions as a precursor to fat-soluble vitamins and steroid hormones. While technically alcohols, sterols are classified by biochemists as lipids (fats in the broader sense of the term).

Some sources make a distinction between sterols and stanols. In this context, the difference between them is analogous to the difference between cholesterol and cholestanol, in that sterols have a double bond between C-5 and C-6, while stanols have not.[6][a]

The gonane skeleton, with the IUPAC recommended numbering of the carbon atoms
  1. ^ "sterol (CHEBI:15889)". www.ebi.ac.uk. Retrieved 2023-11-04. – The formula given is C19H31OR, with an R group attached at the sterol sidechain (C-17) position.
  2. ^ "Sterols (1107)". pubchem.ncbi.nlm.nih.gov. – This source is more confusing, as it does not indicate an R group and simply uses gonan-3-ol for the structure of sterol. Nevertheless, the text clearly indicates that the name is intended for a larger group of compounds, and at no point is "sterol" intended as a synonym of gonan-3-ol.
  3. ^ The International Union of Pure and Applied Chemistry (IUPAC). "IUPAC - sterols (S06006)". goldbook.iupac.org. Natural products derived from the steroid skeleton and containing a hydroxy group in the 3 position, closely related to cholestan-3-ol.
  4. ^ Wei JH, Yin X, Welander PV (24 June 2016). "Sterol Synthesis in Diverse Bacteria". Frontiers in Microbiology. 7: 990. doi:10.3389/fmicb.2016.00990. PMC 4919349. PMID 27446030.
  5. ^ Hoshino Y, Gaucher EA (June 2021). "Evolution of bacterial steroid biosynthesis and its impact on eukaryogenesis". Proceedings of the National Academy of Sciences of the United States of America. 118 (25): e2101276118. Bibcode:2021PNAS..11801276H. doi:10.1073/pnas.2101276118. PMC 8237579. PMID 34131078.
  6. ^ Cantrill, Richard (2008). "PHYTOSTEROLS, PHYTOSTANOLS AND THEIR ESTERS Chemical and Technical Assessment" (PDF). Food and Agriculture Organization of the United Nations.
  7. ^ "stenol, n. meanings, etymology and more". Oxford English Dictionary.


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