2-Butoxyethanol

2-Butoxyethanol
Names
	Preferred IUPAC name 2-Butoxyethanol
	Other names 2-Butoxyethanol; Butyl cellosolve; Butyl glycol; Butyl monoether glycol; EGBE (ethylene glycol monobutyl ether); Dowanol EB; Eastman EB solvent; 2-BE; EGMBE; Butyl oxitol; Ektasolve EB; Jeffersol EB
Identifiers
CAS Number	111-76-2 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:63921 ;
ChEMBL	ChEMBL284588;
ChemSpider	13836399 ;
ECHA InfoCard	100.003.550
EC Number	203-905-0;
PubChem CID	8133;
RTECS number	KJ8575000;
UNII	I0P9XEZ9WV ;
UN number	1993, 2810, 2369
CompTox Dashboard (EPA)	DTXSID1024097 ;
	InChI InChI=1S/C6H14O2/c1-2-3-5-8-6-4-7/h7H,2-6H2,1H3 Key: POAOYUHQDCAZBD-UHFFFAOYSA-N ; InChI=1/C6H14O2/c1-2-3-5-8-6-4-7/h7H,2-6H2,1H3 Key: POAOYUHQDCAZBD-UHFFFAOYAB;
	SMILES OCCOCCCC;
Properties
Chemical formula	C6H14O2
Molar mass	118.176 g·mol−1
Appearance	Clear, colorless liquid
Density	0.90 g/cm3, liquid
Melting point	−77 °C (−107 °F; 196 K)
Boiling point	171 °C (340 °F; 444 K)
Solubility in water	Miscible (and in most organic solvents)
Vapor pressure	0.8 mmHg
Acidity (pKa)	High pKa for −OH group
Refractive index (nD)	1.4198 (20 °C)
Viscosity	2.9 cP at 25 °C (77 °F)
Dipole moment	2.08 D
Hazards
	GHS labelling:
Pictograms
Signal word	Danger
Hazard statements	H227, H302, H311, H315, H319, H330, H336, H361, H370, H372
Precautionary statements	P201, P202, P210, P260, P261, P264, P270, P271, P280, P281, P284, P301+P312, P302+P352, P304+P340, P305+P351+P338, P307+P311, P308+P313, P310, P312, P314, P320, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P370+P378, P403+P233, P403+P235, P405, P501
NFPA 704 (fire diamond)	2 2 0
Flash point	67 °C (153 °F; 340 K)
Autoignition; temperature	245 °C (473 °F; 518 K)
Explosive limits	1.1–12.7%
	Lethal dose or concentration (LD, LC):
LD50 (median dose)	1230 mg/kg (mouse, oral); 470 mg/kg (rat, oral); 300 mg/kg (rabbit, oral); 1200 mg/kg (guinea pig, oral); 1480 mg/kg (rat, oral)
LC50 (median concentration)	450 ppm (rat, 4 hr); 700 ppm (mouse, 7 hr)
	NIOSH (US health exposure limits):
PEL (Permissible)	TWA 50 ppm (240 mg/m3) [skin]
REL (Recommended)	TWA 5 ppm (24 mg/m3) [skin]
IDLH (Immediate danger)	700 ppm
Safety data sheet (SDS)	[1]
Related compounds
Related ethers	2-Methoxyethanol; 2-Ethoxyethanol
Related compounds	Ethylene glycol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

2-Butoxyethanol is an organic compound with the chemical formula BuOC₂H₄OH (Bu = CH₃CH₂CH₂CH₂). This colorless liquid has a sweet, ether-like odor, as it derives from the family of glycol ethers, and is a butyl ether of ethylene glycol. As a relatively nonvolatile, inexpensive solvent, it is used in many domestic and industrial products because of its properties as a surfactant. It is a known respiratory irritant^[4] and can be acutely toxic, but animal studies did not find it to be mutagenic, and no studies suggest it is a human carcinogen.^[5] A study of 13 classroom air contaminants conducted in Portugal reported a statistically significant association with increased rates of nasal obstruction and a positive association below the level of statistical significance with a higher risk of obese asthma and increased body mass index.^[6]

^ ^a ^b ^c ^d ^e NIOSH Pocket Guide to Chemical Hazards. "#0070". National Institute for Occupational Safety and Health (NIOSH).
^ ^a ^b William M. Haynes, ed. (2016). CRC handbook of chemistry and physics : a ready-reference book of chemical and physical data (97th ed.). Boca Raton, Florida: CRC Press. ISBN 978-1-4987-5428-6. OCLC 930681942.
^ ^a ^b "2-Butoxyethanol". Immediately Dangerous to Life or Health Concentrations (IDLH). National Institute for Occupational Safety and Health (NIOSH).
^ "Toxnet Has Moved". www.nlm.nih.gov. Retrieved 2020-01-24.
^ "Public Health Statement for 2-Butoxyethanol and 2-Butoxyethanol Acetate". Agency for Toxic Substances and Disease Registry, Center for Disease Control. August 1998. Retrieved 16 February 2020.
^ Paciência, Inês; Cavaleiro Rufo, João; Silva, Diana; Martins, Carla; Mendes, Francisca; Farraia, Mariana; Delgado, Luís; De Oliveira Fernandes, Eduardo; Padrão, Patrícia; Moreira, Pedro; Severo, Milton; Barros, Henrique; Moreira, André (2019). "Exposure to indoor endocrine-disrupting chemicals and childhood asthma and obesity". Allergy. 74 (7): 1277–1291. doi:10.1111/all.13740. PMID 30740706. S2CID 73443692.

[PGCH-1] NIOSH Pocket Guide to Chemical Hazards. "#0070". National Institute for Occupational Safety and Health (NIOSH).

[CRC97-2] William M. Haynes, ed. (2016). CRC handbook of chemistry and physics : a ready-reference book of chemical and physical data (97th ed.). Boca Raton, Florida: CRC Press. ISBN 978-1-4987-5428-6. OCLC 930681942.

[IDLH-3] "2-Butoxyethanol". Immediately Dangerous to Life or Health Concentrations (IDLH). National Institute for Occupational Safety and Health (NIOSH).

[4] "Toxnet Has Moved". www.nlm.nih.gov. Retrieved 2020-01-24.

[5] "Public Health Statement for 2-Butoxyethanol and 2-Butoxyethanol Acetate". Agency for Toxic Substances and Disease Registry, Center for Disease Control. August 1998. Retrieved 16 February 2020.

[6] Paciência, Inês; Cavaleiro Rufo, João; Silva, Diana; Martins, Carla; Mendes, Francisca; Farraia, Mariana; Delgado, Luís; De Oliveira Fernandes, Eduardo; Padrão, Patrícia; Moreira, Pedro; Severo, Milton; Barros, Henrique; Moreira, André (2019). "Exposure to indoor endocrine-disrupting chemicals and childhood asthma and obesity". Allergy. 74 (7): 1277–1291. doi:10.1111/all.13740. PMID 30740706. S2CID 73443692.

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Names


Preferred IUPAC name 2-Butoxyethanol
Other names 2-Butoxyethanol Butyl cellosolve Butyl glycol Butyl monoether glycol EGBE (ethylene glycol monobutyl ether) Dowanol EB Eastman EB solvent 2-BE EGMBE Butyl oxitol Ektasolve EB Jeffersol EB
Identifiers
CAS Number	111-76-2^Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:63921^N
ChEMBL	ChEMBL284588
ChemSpider	13836399^N
ECHA InfoCard	100.003.550
EC Number	203-905-0
PubChem CID	8133
RTECS number	KJ8575000
UNII	I0P9XEZ9WV^Y
UN number	1993, 2810, 2369
CompTox Dashboard (EPA)	DTXSID1024097
InChI InChI=1S/C6H14O2/c1-2-3-5-8-6-4-7/h7H,2-6H2,1H3^N Key: POAOYUHQDCAZBD-UHFFFAOYSA-N^N InChI=1/C6H14O2/c1-2-3-5-8-6-4-7/h7H,2-6H2,1H3 Key: POAOYUHQDCAZBD-UHFFFAOYAB
SMILES OCCOCCCC
Properties
Chemical formula	C₆H₁₄O₂
Molar mass	118.176 g·mol⁻¹
Appearance	Clear, colorless liquid
Density	0.90 g/cm³, liquid
Melting point	−77 °C (−107 °F; 196 K)
Boiling point	171 °C (340 °F; 444 K)
Solubility in water	Miscible (and in most organic solvents)
Vapor pressure	0.8 mmHg^[1]
Acidity (pK_a)	High pK_a for −OH group
Refractive index (n_D)	1.4198 (20 °C)^[2]
Viscosity	2.9 cP at 25 °C (77 °F)
Dipole moment	2.08 D^[2]
Hazards
GHS labelling:
Pictograms
Signal word	Danger
Hazard statements	H227, H302, H311, H315, H319, H330, H336, H361, H370, H372
Precautionary statements	P201, P202, P210, P260, P261, P264, P270, P271, P280, P281, P284, P301+P312, P302+P352, P304+P340, P305+P351+P338, P307+P311, P308+P313, P310, P312, P314, P320, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P370+P378, P403+P233, P403+P235, P405, P501
NFPA 704 (fire diamond)	2 2 0
Flash point	67 °C (153 °F; 340 K)
Autoignition temperature	245 °C (473 °F; 518 K)
Explosive limits	1.1–12.7%^[1]
Lethal dose or concentration (LD, LC):
LD₅₀ (median dose)	1230 mg/kg (mouse, oral) 470 mg/kg (rat, oral) 300 mg/kg (rabbit, oral) 1200 mg/kg (guinea pig, oral) 1480 mg/kg (rat, oral)^[3]
LC₅₀ (median concentration)	450 ppm (rat, 4 hr) 700 ppm (mouse, 7 hr)^[3]
NIOSH (US health exposure limits):
PEL (Permissible)	TWA 50 ppm (240 mg/m³) [skin]^[1]
REL (Recommended)	TWA 5 ppm (24 mg/m³) [skin]^[1]
IDLH (Immediate danger)	700 ppm^[1]
Safety data sheet (SDS)	[1]
Related compounds
Related ethers	2-Methoxyethanol 2-Ethoxyethanol
Related compounds	Ethylene glycol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is ^YN ?) Infobox references