5-HT1D receptor

HTR1D
Identifiers
Aliases	HTR1D, 5-HT1D, HT1DA, HTR1DA, HTRL, RDC4, 5-HT1D receptor, 5-hydroxytryptamine receptor 1D
External IDs	OMIM: 182133; MGI: 96276; HomoloGene: 20240; GeneCards: HTR1D; OMA:HTR1D - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.12 Start 23,191,895 bp[1] End 23,217,502 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D3|4 68.74 cM Start 136,150,835 bp[2] End 136,171,709 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle nucleus accumbens putamen duodenum caudate nucleus gallbladder gonad ganglionic eminence stromal cell of endometrium prefrontal cortex Top expressed in paraventricular nucleus of thalamus lumbar spinal ganglion lateral habenular nucleus ventral nuclear group lateral preoptic nucleus multiform layer of neocortex medial habenular nucleus ventral nucleus of lateral geniculate body embryo nucleus of lateral olfactory tract More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity G protein-coupled serotonin receptor activity neurotransmitter receptor activity serotonin binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane dendrite Biological process intestine smooth muscle contraction regulation of locomotion smooth muscle contraction G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger regulation of behavior adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway response to toxic substance vasoconstriction signal transduction chemical synaptic transmission G protein-coupled serotonin receptor signaling pathway G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3352 15552 Ensembl ENSG00000179546 ENSMUSG00000070687 UniProt P28221 Q61224 RefSeq (mRNA) NM_000864 NM_001285482 NM_001285483 NM_001285484 NM_008309 RefSeq (protein) NP_000855 NP_001272411 NP_001272412 NP_001272413 NP_032335 Location (UCSC) Chr 1: 23.19 – 23.22 Mb Chr 4: 136.15 – 136.17 Mb PubMed search [3] [4]
Wikidata
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5-hydroxytryptamine (serotonin) receptor 1D, also known as HTR1D, is a 5-HT receptor, but also denotes the human gene encoding it.^[5] 5-HT_1D acts on the central nervous system, and affects locomotion and anxiety. It also induces vasoconstriction in the brain.