5-HT6 receptor

HTR6
Identifiers
Aliases	HTR6, 5-HT6, 5-HT6R, 5-HT6 receptor, 5-hydroxytryptamine receptor 6
External IDs	OMIM: 601109; MGI: 1196627; HomoloGene: 673; GeneCards: HTR6; OMA:HTR6 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	19,680,966 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	138,802,881 bp
RNA expression pattern
	Top expressed in
	beta cell; ; Brodmann area 10; ; pancreatic ductal cell; ; frontal pole; ; mucosa of urinary bladder; ; middle frontal gyrus; ; external globus pallidus; ; body of tongue; ; pericardium; ; inferior ganglion of vagus nerve;
	Top expressed in
	lumbar subsegment of spinal cord; ; superior frontal gyrus; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; ventricular zone; ; cerebellar cortex; ; hippocampus proper; ; neck; ; digastric muscle; ; olfactory bulb;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	histamine receptor activity; protein binding; G protein-coupled receptor activity; signal transducer activity; neurotransmitter receptor activity; G protein-coupled serotonin receptor activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; cilium; membrane; dendrite;
Biological process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; cerebral cortex cell migration; positive regulation of TOR signaling; signal transduction; chemical synaptic transmission; G protein-coupled serotonin receptor signaling pathway; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3362
	15565
	ENSG00000158748
	ENSMUSG00000028747
	P50406
	Q9R1C8
	NM_000871
	NM_021358; NM_001377096
	NP_000862
	NP_067333; NP_001364025
	Wikidata
View/Edit Human	View/Edit Mouse

The 5HT₆ receptor is a subtype of 5HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5HT).^[5] It is a G protein-coupled receptor (GPCR) that is coupled to G_s and mediates excitatory neurotransmission.^[5] HTR6 denotes the human gene encoding for the receptor.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000158748 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028747 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Kohen R, Metcalf MA, Khan N, Druck T, Huebner K, Lachowicz JE, Meltzer HY, Sibley DR, Roth BL, Hamblin MW (January 1996). "Cloning, characterization, and chromosomal localization of a human 5HT₆ serotonin receptor". Journal of Neurochemistry. 66 (1): 47–56. doi:10.1046/j.1471-4159.1996.66010047.x. PMID 8522988. S2CID 35874409.
^ "Entrez Gene: HTR6 5-hydroxytryptamine (serotonin) receptor 6".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000158748 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028747 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8522988-5] Kohen R, Metcalf MA, Khan N, Druck T, Huebner K, Lachowicz JE, Meltzer HY, Sibley DR, Roth BL, Hamblin MW (January 1996). "Cloning, characterization, and chromosomal localization of a human 5HT₆ serotonin receptor". Journal of Neurochemistry. 66 (1): 47–56. doi:10.1046/j.1471-4159.1996.66010047.x. PMID 8522988. S2CID 35874409.

[entrez-6] "Entrez Gene: HTR6 5-hydroxytryptamine (serotonin) receptor 6".

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