5-HT7 receptor

HTR7
Identifiers
Aliases	HTR7, 5-HT7, 5-HT7 receptor, 5-hydroxytryptamine receptor 7
External IDs	OMIM: 182137; MGI: 99841; HomoloGene: 20244; GeneCards: HTR7; OMA:HTR7 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	90,858,039 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	36,034,907 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; sperm; ; secondary oocyte; ; left testis; ; lateral nuclear group of thalamus; ; right testis; ; gastric mucosa; ; Descending thoracic aorta; ; stromal cell of endometrium;
	Top expressed in
	medial dorsal nucleus; ; lateral septal nucleus; ; ventromedial nucleus; ; medial geniculate nucleus; ; mammillary body; ; paraventricular nucleus of hypothalamus; ; utricle; ; lateral geniculate nucleus; ; dorsomedial hypothalamic nucleus; ; lateral hypothalamus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; neurotransmitter receptor activity; G protein-coupled serotonin receptor activity; serotonin binding; protein binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; dendrite;
Biological process	smooth muscle contraction; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; circadian rhythm; blood circulation; vasoconstriction; signal transduction; chemical synaptic transmission; adenylate cyclase-inhibiting serotonin receptor signaling pathway; G protein-coupled receptor signaling pathway; G protein-coupled serotonin receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3363
	15566
	ENSG00000148680
	ENSMUSG00000024798
	P34969
	P32304
	NM_019860; NM_000872; NM_019859
NM_008315; NM_001347442; NM_001360297; NM_001360298; NM_001360300;
	NM_001360318
	NP_000863; NP_062873; NP_062874
NP_001334371; NP_032341; NP_001347226; NP_001347227; NP_001347229;
	NP_001347247
	Wikidata
View/Edit Human	View/Edit Mouse

The 5-HT₇ receptor is a member of the GPCR superfamily of cell surface receptors and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).^[5] The 5-HT₇ receptor is coupled to G_s (stimulates the production of the intracellular signaling molecule cAMP)^[6]^[7] and is expressed in a variety of human tissues, particularly in the brain, the gastrointestinal tract, and in various blood vessels.^[7] This receptor has been a drug development target for the treatment of several clinical disorders.^[8] The 5-HT₇ receptor is encoded by the HTR7 gene, which in humans is transcribed into 3 different splice variants.^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000148680 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024798 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Vanhoenacker P, Haegeman G, Leysen JE (February 2000). "5-HT7 receptors: current knowledge and future prospects". Trends in Pharmacological Sciences. 21 (2): 70–7. doi:10.1016/S0165-6147(99)01432-7. PMID 10664612.
^ Ruat M, Traiffort E, Leurs R, Tardivel-Lacombe J, Diaz J, Arrang JM, Schwartz JC (September 1993). "Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation". Proceedings of the National Academy of Sciences of the United States of America. 90 (18): 8547–51. Bibcode:1993PNAS...90.8547R. doi:10.1073/pnas.90.18.8547. PMC 47394. PMID 8397408.
^ ^a ^b Bard JA, Zgombick J, Adham N, Vaysse P, Branchek TA, Weinshank RL (November 1993). "Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase". The Journal of Biological Chemistry. 268 (31): 23422–6. doi:10.1016/S0021-9258(19)49479-9. PMID 8226867.
^ Mnie-Filali O, Lambás-Señas L, Zimmer L, Haddjeri N (December 2007). "5-HT7 receptor antagonists as a new class of antidepressants". Drug News & Perspectives. 20 (10): 613–8. doi:10.1358/dnp.2007.20.10.1181354. PMID 18301795.
^ Heidmann DE, Metcalf MA, Kohen R, Hamblin MW (April 1997). "Four 5-hydroxytryptamine7 (5-HT7) receptor isoforms in human and rat produced by alternative splicing: species differences due to altered intron-exon organization". Journal of Neurochemistry. 68 (4): 1372–81. doi:10.1046/j.1471-4159.1997.68041372.x. PMID 9084407. S2CID 25951920.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000148680 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024798 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10664612-5] Vanhoenacker P, Haegeman G, Leysen JE (February 2000). "5-HT7 receptors: current knowledge and future prospects". Trends in Pharmacological Sciences. 21 (2): 70–7. doi:10.1016/S0165-6147(99)01432-7. PMID 10664612.

[pmid8397408-6] Ruat M, Traiffort E, Leurs R, Tardivel-Lacombe J, Diaz J, Arrang JM, Schwartz JC (September 1993). "Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation". Proceedings of the National Academy of Sciences of the United States of America. 90 (18): 8547–51. Bibcode:1993PNAS...90.8547R. doi:10.1073/pnas.90.18.8547. PMC 47394. PMID 8397408.

[pmid8226867-7] Bard JA, Zgombick J, Adham N, Vaysse P, Branchek TA, Weinshank RL (November 1993). "Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase". The Journal of Biological Chemistry. 268 (31): 23422–6. doi:10.1016/S0021-9258(19)49479-9. PMID 8226867.

[pmid18301795-8] Mnie-Filali O, Lambás-Señas L, Zimmer L, Haddjeri N (December 2007). "5-HT7 receptor antagonists as a new class of antidepressants". Drug News & Perspectives. 20 (10): 613–8. doi:10.1358/dnp.2007.20.10.1181354. PMID 18301795.

[pmid9084407-9] Heidmann DE, Metcalf MA, Kohen R, Hamblin MW (April 1997). "Four 5-hydroxytryptamine7 (5-HT7) receptor isoforms in human and rat produced by alternative splicing: species differences due to altered intron-exon organization". Journal of Neurochemistry. 68 (4): 1372–81. doi:10.1046/j.1471-4159.1997.68041372.x. PMID 9084407. S2CID 25951920.

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