ALPL

ALPL
Identifiers
Aliases	ALPL, AP-TNAP, APTNAP, HOPS, TNAP, TNSALP, alkaline phosphatase, liver/bone/kidney, TNALP, alkaline phosphatase, biomineralization associated, HPPA, HPPI, HPPC, HPPO, TNS-ALP
External IDs	OMIM: 171760; MGI: 87983; HomoloGene: 37314; GeneCards: ALPL; OMA:ALPL - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	21,578,410 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	137,523,695 bp
RNA expression pattern
	Top expressed in
	right adrenal gland; ; right adrenal cortex; ; left adrenal cortex; ; right lobe of liver; ; upper lobe of lung; ; upper lobe of left lung; ; gonad; ; blood; ; right lung; ; lower lobe of lung;
	Top expressed in
	molar; ; calvaria; ; body of femur; ; blastocyst; ; right kidney; ; neural layer of retina; ; human kidney; ; transitional epithelium of urinary bladder; ; facial skeleton; ; jaw;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding; hydrolase activity; alkaline phosphatase activity; catalytic activity; pyrophosphatase activity; phosphatase activity;
Cellular component	integral component of membrane; anchored component of membrane; membrane; extracellular membrane-bounded organelle; extracellular exosome; extracellular region; extracellular space; plasma membrane; extracellular matrix;
Biological process	response to lipopolysaccharide; osteoblast differentiation; biomineral tissue development; cementum mineralization; cellular response to organic cyclic compound; skeletal system development; metabolism; dephosphorylation; response to vitamin D; response to antibiotic; developmental process involved in reproduction; response to glucocorticoid; endochondral ossification; C-terminal protein lipidation;
	Sources:Amigo / QuickGO
Orthologs
	249
	11647
	ENSG00000162551
	ENSMUSG00000028766
	P05186
	P09242
NM_000478; NM_001127501; NM_001177520; NM_001369803; NM_001369804;
	NM_001369805
	NM_001287172; NM_001287176; NM_007431
NP_000469; NP_001120973; NP_001170991; NP_001356732; NP_001356733;
	NP_001356734
	NP_001274101; NP_031457
	Wikidata
View/Edit Human	View/Edit Mouse

Alkaline phosphatase, tissue-nonspecific isozyme (TNAP) is an enzyme that in humans is encoded by the ALPL gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162551 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028766 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Weiss MJ, Henthorn PS, Lafferty MA, Slaughter C, Raducha M, Harris H (October 1986). "Isolation and characterization of a cDNA encoding a human liver/bone/kidney-type alkaline phosphatase". Proceedings of the National Academy of Sciences of the United States of America. 83 (19): 7182–7186. Bibcode:1986PNAS...83.7182W. doi:10.1073/pnas.83.19.7182. PMC 386679. PMID 3532105.
^ Swallow DM, Povey S, Parkar M, Andrews PW, Harris H, Pym B, et al. (July 1986). "Mapping of the gene coding for the human liver/bone/kidney isozyme of alkaline phosphatase to chromosome 1". Annals of Human Genetics. 50 (3): 229–235. doi:10.1111/j.1469-1809.1986.tb01043.x. PMID 3446011. S2CID 20363222.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162551 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028766 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3532105-5] Weiss MJ, Henthorn PS, Lafferty MA, Slaughter C, Raducha M, Harris H (October 1986). "Isolation and characterization of a cDNA encoding a human liver/bone/kidney-type alkaline phosphatase". Proceedings of the National Academy of Sciences of the United States of America. 83 (19): 7182–7186. Bibcode:1986PNAS...83.7182W. doi:10.1073/pnas.83.19.7182. PMC 386679. PMID 3532105.

[pmid3446011-6] Swallow DM, Povey S, Parkar M, Andrews PW, Harris H, Pym B, et al. (July 1986). "Mapping of the gene coding for the human liver/bone/kidney isozyme of alkaline phosphatase to chromosome 1". Annals of Human Genetics. 50 (3): 229–235. doi:10.1111/j.1469-1809.1986.tb01043.x. PMID 3446011. S2CID 20363222.

[1]

[2]

[3]

[4]

[5]

[6]