Albendazole

Albendazole
Clinical data
Trade names	Albenza, Eskazole, Valbazen, Zentel, others
AHFS/Drugs.com	Monograph
MedlinePlus	a610019
License data	US DailyMed: Albendazole;
Pregnancy; category	AU: D; ;
Routes of; administration	By mouth
ATC code	P02CA03 (WHO) QP52AC11 (WHO);
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; UK: POM (Prescription only); US: ℞-only (for humans; veterinary suspension and paste are both OTC);
Pharmacokinetic data
Bioavailability	<5%
Protein binding	70%
Metabolism	Liver
Elimination half-life	8–12 hours
Excretion	Bile duct (humans); Kidney (ruminants)
Identifiers
CAS Number	54965-21-8 ;
PubChem CID	2082;
DrugBank	DB00518 ;
ChemSpider	1998 ;
UNII	F4216019LN;
KEGG	D00134 ;
ChEBI	CHEBI:16664 ;
ChEMBL	ChEMBL1483 ;
NIAID ChemDB	007895;
CompTox Dashboard (EPA)	DTXSID0022563 ;
ECHA InfoCard	100.053.995
Chemical and physical data
Formula	C12H15N3O2S
Molar mass	265.33 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	208 to 210 °C (406 to 410 °F)
	SMILES CCCSc2ccc1nc(NC(=O)OC)[nH]c1c2;
	InChI InChI=1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16) ; Key:HXHWSAZORRCQMX-UHFFFAOYSA-N ;
	(verify)

Albendazole is a broad-spectrum antihelmintic and antiprotozoal agent of the benzimidazole type.^[3] It is used for the treatment of a variety of intestinal parasite infections, including ascariasis, pinworm infection, hookworm infection, trichuriasis, strongyloidiasis, taeniasis, clonorchiasis, opisthorchiasis, cutaneous larva migrans, giardiasis, and gnathostomiasis, among other diseases.^[3]

Common side effects include nausea, abdominal pain, and headache.^[3] Rare but potentially serious side effects include bone marrow suppression which usually improves on discontinuing the medication. Liver inflammation has been reported and those with prior liver problems are at greater risk.^[3] It is pregnancy category D in Australia, meaning it may cause harm if taken by pregnant women.^[3]^[4]

Albendazole was developed in 1975. ^[5] It is on the World Health Organization's List of Essential Medicines.^[6]

^ Cite error: The named reference plumb was invoked but never defined (see the help page).
^ ^a ^b ^c ^d Cite error: The named reference MSR was invoked but never defined (see the help page).
^ ^a ^b ^c ^d ^e "Albendazole". Drugs.com. The American Society of Health-System Pharmacists. Archived from the original on September 23, 2015. Retrieved August 18, 2015.
^ Australian Government (March 3, 2014). "Prescribing medicines in pregnancy database". Archived from the original on April 8, 2014. Retrieved April 22, 2014.
^ Neonatal Formulary: Drug Use in Pregnancy and the First Year of Life. John Wiley & Sons. 2014. p. 64. ISBN 9781118819593. Archived from the original on 2017-09-08.
^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.

[plumb-1] Cite error: The named reference plumb was invoked but never defined (see the help page).

[MSR-2] Cite error: The named reference MSR was invoked but never defined (see the help page).

[AHFS2015-3] "Albendazole". Drugs.com. The American Society of Health-System Pharmacists. Archived from the original on September 23, 2015. Retrieved August 18, 2015.

[4] Australian Government (March 3, 2014). "Prescribing medicines in pregnancy database". Archived from the original on April 8, 2014. Retrieved April 22, 2014.

[5] Neonatal Formulary: Drug Use in Pregnancy and the First Year of Life. John Wiley & Sons. 2014. p. 64. ISBN 9781118819593. Archived from the original on 2017-09-08.

[WHO22nd-6] World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.

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