Back أجسام مضادة للغدة الدرقية Arabic Αντιθυρεοειδικά αντισώματα Greek Anticorps anti-thyroïdiens French 甲状腺自己抗体 Japanese Schildklierautoantistoffen Dutch Антитиреоидные аутоантитела Russian 抗甲狀腺自體抗體 Chinese
Antithyroid autoantibodies (or simply antithyroid antibodies) are autoantibodies targeted against one or more components on the thyroid. The most clinically relevant anti-thyroid autoantibodies are anti-thyroid peroxidase antibodies (anti-TPO antibodies, TPOAb), thyrotropin receptor antibodies (TRAb) and thyroglobulin antibodies (TgAb). TRAb's are subdivided into activating, blocking and neutral antibodies, depending on their effect on the TSH receptor. Anti-sodium/iodide (Anti–Na+/I−) symporter antibodies are a more recent discovery and their clinical relevance is still unknown. Graves' disease and Hashimoto's thyroiditis are commonly associated with the presence of anti-thyroid autoantibodies. Although there is overlap, anti-TPO antibodies are most commonly associated with Hashimoto's thyroiditis and activating TRAb's are most commonly associated with Graves' disease. Thyroid microsomal antibodies were a group of anti-thyroid antibodies; they were renamed after the identification of their target antigen (TPO).[1][2][3][4]
- ^ Saravanan P, Dayan CM (June 2001). "Thyroid autoantibodies". Endocrinology and Metabolism Clinics of North America. 30 (2): 315–37, viii. doi:10.1016/S0889-8529(05)70189-4. PMID 11444165.
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