Aromatase

CYP19A1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3EQM, 3S79, 3S7S, 4GL5, 4GL7, 4KQ8
Identifiers
Aliases	CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM, cytochrome P450 family 19 subfamily A member 1
External IDs	OMIM: 107910; MGI: 88587; HomoloGene: 30955; GeneCards: CYP19A1; OMA:CYP19A1 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q21.2 Start 51,208,057 bp[1] End 51,338,601 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A5.3|9 29.49 cM Start 54,073,221 bp[2] End 54,175,394 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta right testis left testis testicle tibial nerve gonad germinal epithelium subcutaneous adipose tissue right ovary left coronary artery Top expressed in spermatocyte secondary oocyte zygote primary oocyte cumulus cell ovarian follicle cell spermatid meninges testicle seminiferous tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function iron ion binding oxygen binding metal ion binding monooxygenase activity heme binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen electron transfer activity oxidoreductase activity aromatase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen steroid hydroxylase activity Cellular component endoplasmic reticulum membrane endoplasmic reticulum membrane integral component of membrane Biological process estrogen biosynthetic process androgen metabolic process negative regulation of chronic inflammatory response prostate gland growth sterol metabolic process negative regulation of macrophage chemotaxis steroid biosynthetic process female gonad development female genitalia development mammary gland development uterus development testosterone biosynthetic process androgen catabolic process positive regulation of estradiol secretion electron transport chain Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1588 13075 Ensembl ENSG00000137869 ENSMUSG00000032274 UniProt P11511 P28649 RefSeq (mRNA) NM_000103 NM_001347248 NM_001347249 NM_001347250 NM_001347251 NM_001347252 NM_001347253 NM_001347254 NM_001347255 NM_001347256 NM_031226 NM_007810 NM_001348171 NM_001348172 NM_001348173 RefSeq (protein) NP_000094 NP_001334177 NP_001334178 NP_001334179 NP_001334180 NP_001334181 NP_001334182 NP_001334183 NP_001334184 NP_001334185 NP_112503 NP_001335100 NP_001335101 NP_001335102 NP_031836 Location (UCSC) Chr 15: 51.21 – 51.34 Mb Chr 9: 54.07 – 54.18 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Aromatase (EC 1.14.14.14), also called estrogen synthetase or estrogen synthase, is an enzyme responsible for a key step in the biosynthesis of estrogens. It is CYP19A1, a member of the cytochrome P450 superfamily, which are monooxygenases that catalyze many reactions involved in steroidogenesis. In particular, aromatase is responsible for the aromatization of androgens into estrogens. The enzyme aromatase can be found in many tissues including gonads (granulosa cells), brain, adipose tissue, placenta, blood vessels, skin, and bone, as well as in tissue of endometriosis, uterine fibroids, breast cancer, and endometrial cancer.^{[citation needed]} It is an important factor in sexual development.