Artemether/lumefantrine

Artemether/lumefantrine
Combination of
Artemether	Antimalarial
Lumefantrine	Antimalarial
Clinical data
Trade names	Coartem, Riamet, Falcynate-LF
AHFS/Drugs.com	Monograph
MedlinePlus	a609024
Pregnancy; category	AU: D; ;
Routes of; administration	By mouth
ATC code	P01BF01 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); US: ℞-only;
Identifiers
CAS Number	141204-94-6;
ChemSpider	21106282 ;
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Artemether/lumefantrine, sold under the trade name Coartem among others, is a combination of the two medications artemether and lumefantrine.^[1] It is used to treat malaria caused by Plasmodium falciparum that is not treatable with chloroquine.^[1] It is not typically used to prevent malaria.^[1] It is taken by mouth.^[1]

Common side effects include muscle and joint pains, fever, loss of appetite, and headache.^[1] Serious side effects include prolongation of the QT interval.^[1] While not well studied, it appears to be safe for use in pregnancy.^[1] The dose does not need changing in those with mild or moderate kidney or liver problems.^[1]

This combination came into medical use in 1992^[2] and was developed in China.^[2]^[3] It is on the World Health Organization's List of Essential Medicines.^[4] It is not available as a generic medication.^[5]

^ ^a ^b ^c ^d ^e ^f ^g ^h "Artemether and Lumefantrine". The American Society of Health-System Pharmacists. Archived from the original on 2015-12-08. Retrieved Dec 2, 2015.
^ ^a ^b Ravina, Enrique (2011). The evolution of drug discovery : from traditional medicines to modern drugs (1. Aufl. ed.). Weinheim: Wiley-VCH. p. 139. ISBN 9783527326693. Archived from the original on 2015-12-08.
^ Nightingale, Charles H. (2007). Antimicrobial pharmacodynamics in theory and clinical practice (2nd ed.). New York: Informa Healthcare. p. 380. ISBN 9781420017137. Archived from the original on 2015-12-08.
^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 45. ISBN 9781284057560.

[AHFS2015-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h "Artemether and Lumefantrine". The American Society of Health-System Pharmacists. Archived from the original on 2015-12-08. Retrieved Dec 2, 2015.

[Enr2011-2] Ravina, Enrique (2011). The evolution of drug discovery : from traditional medicines to modern drugs (1. Aufl. ed.). Weinheim: Wiley-VCH. p. 139. ISBN 9783527326693. Archived from the original on 2015-12-08.

[3] Nightingale, Charles H. (2007). Antimicrobial pharmacodynamics in theory and clinical practice (2nd ed.). New York: Informa Healthcare. p. 380. ISBN 9781420017137. Archived from the original on 2015-12-08.

[WHO21st-4] World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.

[Ric2015-5] Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 45. ISBN 9781284057560.

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