Autoimmunity

Autoimmunity
Autoimmunity
	Parts of body affected by autoimmune diseases
Specialty	Immunology

In immunology, autoimmunity is the system of immune responses of an organism against its own healthy cells, tissues and other normal body constituents.^[1]^[2] Any disease resulting from this type of immune response is termed an "autoimmune disease". Prominent examples include celiac disease, diabetes mellitus type 1, Henoch–Schönlein purpura, systemic lupus erythematosus, Sjögren syndrome, eosinophilic granulomatosis with polyangiitis, Hashimoto's thyroiditis, Graves' disease, idiopathic thrombocytopenic purpura, Addison's disease, rheumatoid arthritis, ankylosing spondylitis, polymyositis, dermatomyositis, and multiple sclerosis. Autoimmune diseases are very often treated with steroids.^[3]

Autoimmunity means presence of antibodies or T cells that react with self-protein and is present in all individuals, even in normal health state. It causes autoimmune diseases if self-reactivity can lead to tissue damage.^[4]

^ The Editors of Encyclopaedia Britannica (20 November 2018). "Autoimmunity". Health & Medicine. Encyclopædia Britannica. Archived from the original on 5 January 2021. Retrieved 5 January 2020.
^ Delves PJ (1998-01-01). "Autoimmunity". In Delves PJ (ed.). Encyclopedia of Immunology (Second ed.). Oxford: Elsevier. pp. 292–296. doi:10.1006/rwei.1999.0075. ISBN 978-0-12-226765-9. Retrieved 2021-01-06.
^ Patt H, Bandgar T, Lila A, Shah N (December 2013). "Management issues with exogenous steroid therapy". Indian Journal of Endocrinology and Metabolism. 17 (Suppl 3): S612–S617. doi:10.4103/2230-8210.123548. PMC 4046616. PMID 24910822.
^ Diamond B, Lipsky PE (2014). "Autoimmunity and Autoimmune Diseases". In Kasper D, Fauci A, Hauser S, Longo D (eds.). Harrison's Principles of Internal Medicine (19th ed.). New York, NY: McGraw-Hill Education. Archived from the original on 5 January 2021. Retrieved 2021-01-05.

[1] The Editors of Encyclopaedia Britannica (20 November 2018). "Autoimmunity". Health & Medicine. Encyclopædia Britannica. Archived from the original on 5 January 2021. Retrieved 5 January 2020.

[2] Delves PJ (1998-01-01). "Autoimmunity". In Delves PJ (ed.). Encyclopedia of Immunology (Second ed.). Oxford: Elsevier. pp. 292–296. doi:10.1006/rwei.1999.0075. ISBN 978-0-12-226765-9. Retrieved 2021-01-06.

[pmid24910822-3] Patt H, Bandgar T, Lila A, Shah N (December 2013). "Management issues with exogenous steroid therapy". Indian Journal of Endocrinology and Metabolism. 17 (Suppl 3): S612–S617. doi:10.4103/2230-8210.123548. PMC 4046616. PMID 24910822.

[4] Diamond B, Lipsky PE (2014). "Autoimmunity and Autoimmune Diseases". In Kasper D, Fauci A, Hauser S, Longo D (eds.). Harrison's Principles of Internal Medicine (19th ed.). New York, NY: McGraw-Hill Education. Archived from the original on 5 January 2021. Retrieved 2021-01-05.

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