Back بائوکیستین AZB Baeocystin German Baeocistina Spanish Baeokystiini Finnish Béocystine French Baeocistina Italian ベオシスチン Japanese Baeocystyna Polish Беоцистин Russian Baeocistin Serbo-Croatian

Baeocystin

Baeocystin
Skeletal formula of baeocystin as a zwitterion
Space-filling model of the baeocystin molecule as a zwitterion
Clinical data
Routes of
administration		Oral
ATC code
  • none
Legal status
Legal status
Identifiers
  • 3-[2-(Methylammonio)ethyl]-1H-indol-4-yl hydrogenphosphate
CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC11H15N2O4P
Molar mass270.225 g·mol−1
3D model (JSmol)
  • CNCCc1c[nH]c2cccc(OP(=O)(O)O)c12
  • InChI=1S/C11H15N2O4P/c1-12-6-5-8-7-13-9-3-2-4-10(11(8)9)17-18(14,15)16/h2-4,7,12-13H,5-6H2,1H3,(H2,14,15,16) checkY
  • Key:WTPBXXCVZZZXKR-UHFFFAOYSA-N checkY
  (verify)

Baeocystin is a zwitterionic alkaloid and analog of psilocybin. It is found as a minor compound in most psilocybin mushrooms together with psilocybin, norbaeocystin, aeruginascin, and psilocin.[1] Baeocystin is an N-demethylated derivative of psilocybin, and a phosphorylated derivative of 4-HO-NMT (4-hydroxy-N-methyltryptamine). The structures at right illustrate baeocystin in its zwitterionic form.

Baeocystin was first isolated from the mushroom Psilocybe baeocystis,[2] and later from P. semilanceata,[3] Panaeolus renenosus, Panaeolus subbalteatus, and Copelandia chlorocystis.[4] It was first synthesized by Troxler et al. in 1959.[5]

Little information exists with regard to human pharmacology, but in the book Magic Mushrooms Around the World, author Jochen Gartz reports being aware of a study in which "10 mg of baeocystin were found to be about as psychoactive as a similar amount of psilocybin."[6] Gartz also reported in a research paper that a self-administered assay of 4 mg of baeocystin caused "a gentle hallucinogenic experience".[7]

While Gartz describes experiencing a "gentle hallucinogenic experience" from baeocystin, this could not be replicated in a mouse model in a 2019 study which found no evidence that baeocystin produces any hallucinogenic effects.[8] Researchers compared psilocybin which is a known hallucinogen to baeocystin by using the mouse head-twitch response. Upon comparison, baeocystin was indistinguishable from saline solution, indicating "...baeocystin alone would likely not induce hallucinogenic effects in vivo". This does contrast however with the human experiences mentioned above, although high quality data is scarce.

  1. ^ Gotvaldová K, Borovička J, Hájková K, Cihlářová P, Rockefeller A, Kuchař M (November 2022). "Extensive Collection of Psychotropic Mushrooms with Determination of Their Tryptamine Alkaloids". International Journal of Molecular Sciences. 23 (22): 14068. doi:10.3390/ijms232214068. PMC 9693126. PMID 36430546.
  2. ^ Cite error: The named reference Leung 1968 was invoked but never defined (see the help page).
  3. ^ Cite error: The named reference Repke 1977 was invoked but never defined (see the help page).
  4. ^ Cite error: The named reference Brossi 1988 was invoked but never defined (see the help page).
  5. ^ Cite error: The named reference Troxer 1959 was invoked but never defined (see the help page).
  6. ^ Cite error: The named reference Gartz1997 was invoked but never defined (see the help page).
  7. ^ Cite error: The named reference Gartz 1991 was invoked but never defined (see the help page).
  8. ^ Cite error: The named reference Sherwood 2019 was invoked but never defined (see the help page).

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