Beta-2 adrenergic receptor

ADRB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4QKX, 2R4R, 2R4S, 2RH1, 3D4S, 3KJ6, 3NY8, 3NY9, 3NYA, 3P0G, 3PDS, 3SN6, 4GBR, 4LDE, 4LDL, 4LDO, 5D5A, 5D5B, 5JQH
Identifiers
Aliases	ADRB2, ADRB2R, ADRBR, B2AR, BAR, BETA2AR, adrenoceptor beta 2
External IDs	OMIM: 109690; MGI: 87938; HomoloGene: 30948; GeneCards: ADRB2; OMA:ADRB2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q32 Start 148,826,611 bp[1] End 148,828,623 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 E1|18 35.1 cM Start 62,310,887 bp[2] End 62,313,030 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue granulocyte skin of thigh gingival epithelium palpebral conjunctiva skin of abdomen lower lobe of lung right lung subcutaneous adipose tissue Skeletal muscle tissue of biceps brachii Top expressed in granulocyte corneal stroma left lung lobe stroma of bone marrow right lung right lung lobe muscle of thigh intercostal muscle blood spleen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function adenylate cyclase binding adrenergic receptor activity beta2-adrenergic receptor activity enzyme binding protein homodimerization activity potassium channel regulator activity protein binding G protein-coupled receptor activity signal transducer activity norepinephrine binding epinephrine binding amyloid-beta binding protein-containing complex binding Cellular component endosome membrane nucleus apical plasma membrane lysosome integral component of membrane receptor complex plasma membrane early endosome integral component of plasma membrane endosome membrane clathrin-coated vesicle membrane Biological process positive regulation of autophagosome maturation adenylate cyclase-activating G protein-coupled receptor signaling pathway regulation of sodium ion transport endosome to lysosome transport receptor-mediated endocytosis cell surface receptor signaling pathway regulation of systemic arterial blood pressure by norepinephrine-epinephrine negative regulation of smooth muscle contraction regulation of smooth muscle contraction adenylate cyclase-modulating G protein-coupled receptor signaling pathway bone resorption adenylate cyclase-activating adrenergic receptor signaling pathway heat generation desensitization of G protein-coupled receptor signaling pathway by arrestin positive regulation of MAPK cascade G protein-coupled receptor signaling pathway positive regulation of bone mineralization activation of adenylate cyclase activity brown fat cell differentiation activation of transmembrane receptor protein tyrosine kinase activity positive regulation of protein ubiquitination negative regulation of multicellular organism growth cell-cell signaling diet induced thermogenesis norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure positive regulation of lipophagy response to cold positive regulation of transcription by RNA polymerase II signal transduction protein deubiquitination membrane organization adrenergic receptor signaling pathway blood vessel diameter maintenance positive regulation of protein kinase A signaling positive regulation of mini excitatory postsynaptic potential positive regulation of protein serine/threonine kinase activity positive regulation of cold-induced thermogenesis cellular response to amyloid-beta response to psychosocial stress positive regulation of cAMP-dependent protein kinase activity positive regulation of AMPA receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 154 11555 Ensembl ENSG00000169252 ENSMUSG00000045730 UniProt P07550 P18762 RefSeq (mRNA) NM_000024 NM_007420 RefSeq (protein) NP_000015 NP_031446 Location (UCSC) Chr 5: 148.83 – 148.83 Mb Chr 18: 62.31 – 62.31 Mb PubMed search [3] [4]
Wikidata
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The beta-2 adrenergic receptor (β₂ adrenoreceptor), also known as ADRB2, is a cell membrane-spanning beta-adrenergic receptor that binds epinephrine (adrenaline), a hormone and neurotransmitter whose signaling, via adenylate cyclase stimulation through trimeric G_s proteins, increases cAMP, and, via downstream L-type calcium channel interaction, mediates physiologic responses such as smooth muscle relaxation and bronchodilation.^[5]

Robert J. Lefkowitz^[6] and Brian Kobilka^[7] studied beta 2 adrenergic receptor as a model system which rewarded them the 2012 Nobel Prize in Chemistry^[8] “for groundbreaking discoveries that reveal the inner workings of an important family of such receptors: G-protein-coupled-receptors”.

The official symbol for the human gene encoding the β₂ adrenoreceptor is ADRB2.^[9]