Brain-derived neurotrophic factor

BDNF
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BND, 1B8M
Identifiers
Aliases	BDNF, brain-derived neurotrophic factor, ANON2, BULN2, Brain-derived neurotrophic factor, brain derived neurotrophic factor
External IDs	OMIM: 113505; MGI: 88145; HomoloGene: 7245; GeneCards: BDNF; OMA:BDNF - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	27,722,058 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	109,557,352 bp
RNA expression pattern
	Top expressed in
	saphenous vein; ; Pons; ; oocyte; ; vena cava; ; secondary oocyte; ; stromal cell of endometrium; ; corpus epididymis; ; testicle; ; buccal mucosa cell; ; apex of heart;
	Top expressed in
	lumbar spinal ganglion; ; CA3 field; ; utricle; ; hippocampus proper; ; perirhinal cortex; ; dentate gyrus; ; entorhinal cortex; ; cingulate gyrus; ; Amygdala; ; interventricular septum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signaling receptor binding; neurotrophin TRKB receptor binding; growth factor activity; protein binding;
Cellular component	cytoplasm; perinuclear region of cytoplasm; mitochondrion; nuclear speck; cytoplasmic vesicle; extracellular region; extracellular space; synaptic vesicle; axon; dendrite;
Biological process	brain-derived neurotrophic factor receptor signaling pathway; negative regulation of neuron apoptotic process; synapse assembly; cell-cell signaling; positive regulation of brain-derived neurotrophic factor receptor signaling pathway; collateral sprouting; positive regulation of synapse assembly; positive regulation of collateral sprouting; nervous system development; axon guidance; negative regulation of myotube differentiation; positive regulation of receptor binding; regulation of protein localization to cell surface; regulation of signaling receptor activity; activation of phospholipase C activity; neurotrophin TRK receptor signaling pathway; positive regulation of non-membrane spanning protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase signaling pathway; peripheral nervous system development; memory; nerve development; nerve growth factor signaling pathway; regulation of neuron differentiation; neuron projection morphogenesis; modulation of chemical synaptic transmission; positive regulation of neuron projection development; negative regulation of apoptotic signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	627
	12064
	ENSG00000176697
	ENSMUSG00000048482
	P23560
	P21237
NM_001143805; NM_001143806; NM_001143807; NM_001143808; NM_001143809;
	NM_001143810; NM_001143811; NM_001143812; NM_001143813; NM_001143814; NM_001143815; NM_001143816; NM_001709; NM_170731; NM_170732; NM_170733; NM_170734; NM_170735
NM_001048139; NM_001048141; NM_001048142; NM_007540; NM_001285416;
	NM_001285417; NM_001285418; NM_001285419; NM_001285420; NM_001285421; NM_001285422; NM_001316310
NP_001137277; NP_001137278; NP_001137279; NP_001137280; NP_001137281;
	NP_001137282; NP_001137283; NP_001137284; NP_001137285; NP_001137286; NP_001137288; NP_001700; NP_733927; NP_733928; NP_733929; NP_733930; NP_733931
NP_001041604; NP_001041606; NP_001041607; NP_001272345; NP_001272346;
	NP_001272347; NP_001272348; NP_001272349; NP_001272350; NP_001272351; NP_001303239; NP_031566
	Wikidata
View/Edit Human	View/Edit Mouse

Brain-derived neurotrophic factor (BDNF), or abrineurin,^[5] is a protein^[6] that, in humans, is encoded by the BDNF gene.^[7]^[8] BDNF is a member of the neurotrophin family of growth factors, which are related to the canonical nerve growth factor (NGF), a family which also includes NT-3 and NT-4/NT-5. Neurotrophic factors are found in the brain and the periphery. BDNF was first isolated from a pig brain in 1982 by Yves-Alain Barde and Hans Thoenen.^[9]

BDNF activates the TrkB tyrosine kinase receptor.^[10]^[11]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000176697 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000048482 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Anti-Brain Derived Neurotrophic Factor Antibody, pro". sigmaaldrich.com. Retrieved 20 August 2023.
^ Binder DK, Scharfman HE (September 2004). "Brain-derived neurotrophic factor". Growth Factors. 22 (3): 123–31. doi:10.1080/08977190410001723308. PMC 2504526. PMID 15518235. found in the ^{[clarification needed]} and the periphery.
^ Jones KR, Reichardt LF (October 1990). "Molecular cloning of a human gene that is a member of the nerve growth factor family". Proceedings of the National Academy of Sciences of the United States of America. 87 (20): 8060–64. Bibcode:1990PNAS...87.8060J. doi:10.1073/pnas.87.20.8060. PMC 54892. PMID 2236018.
^ Maisonpierre PC, Le Beau MM, Espinosa R, Ip NY, Belluscio L, de la Monte SM, et al. (July 1991). "Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations". Genomics. 10 (3): 558–68. doi:10.1016/0888-7543(91)90436-I. PMID 1889806.
^ Kowiański P, Lietzau G, Czuba E, Waśkow M, Steliga A, Moryś J (April 2018). "BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity". Cellular and Molecular Neurobiology. 38 (3): 579–593. doi:10.1007/s10571-017-0510-4. PMC 5835061. PMID 28623429.
^ Squinto SP, Stitt TN, Aldrich TH, Valenzuela DM, DiStefano PS, Yancopoulos GD (May 1991). "trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor". Cell. 65 (5): 885–893. doi:10.1016/0092-8674(91)90395-f. PMID 1710174. S2CID 28853455.
^ Glass DJ, Nye SH, Hantzopoulos P, Macchi MJ, Squinto SP, Goldfarb M, et al. (July 1991). "TrkB mediates BDNF/NT-3-dependent survival and proliferation in fibroblasts lacking the low affinity NGF receptor". Cell. 66 (2): 405–413. doi:10.1016/0092-8674(91)90629-d. PMID 1649703. S2CID 43626580.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000176697 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000048482 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "Anti-Brain Derived Neurotrophic Factor Antibody, pro". sigmaaldrich.com. Retrieved 20 August 2023.

[pmid15518235-6] Binder DK, Scharfman HE (September 2004). "Brain-derived neurotrophic factor". Growth Factors. 22 (3): 123–31. doi:10.1080/08977190410001723308. PMC 2504526. PMID 15518235. found in the ^{[clarification needed]} and the periphery.

[pmid2236018-7] Jones KR, Reichardt LF (October 1990). "Molecular cloning of a human gene that is a member of the nerve growth factor family". Proceedings of the National Academy of Sciences of the United States of America. 87 (20): 8060–64. Bibcode:1990PNAS...87.8060J. doi:10.1073/pnas.87.20.8060. PMC 54892. PMID 2236018.

[pmid1889806-8] Maisonpierre PC, Le Beau MM, Espinosa R, Ip NY, Belluscio L, de la Monte SM, et al. (July 1991). "Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations". Genomics. 10 (3): 558–68. doi:10.1016/0888-7543(91)90436-I. PMID 1889806.

[9] Kowiański P, Lietzau G, Czuba E, Waśkow M, Steliga A, Moryś J (April 2018). "BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity". Cellular and Molecular Neurobiology. 38 (3): 579–593. doi:10.1007/s10571-017-0510-4. PMC 5835061. PMID 28623429.

[auto-10] Squinto SP, Stitt TN, Aldrich TH, Valenzuela DM, DiStefano PS, Yancopoulos GD (May 1991). "trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor". Cell. 65 (5): 885–893. doi:10.1016/0092-8674(91)90395-f. PMID 1710174. S2CID 28853455.

[auto1-11] Glass DJ, Nye SH, Hantzopoulos P, Macchi MJ, Squinto SP, Goldfarb M, et al. (July 1991). "TrkB mediates BDNF/NT-3-dependent survival and proliferation in fibroblasts lacking the low affinity NGF receptor". Cell. 66 (2): 405–413. doi:10.1016/0092-8674(91)90629-d. PMID 1649703. S2CID 43626580.

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