Brassinosteroid

Brassinosteroids (BRs or less commonly BS)^[1] are a class of polyhydroxysteroids that have been recognized as a sixth class of plant hormones and may have utility as anticancer drugs for treating endocrine-responsive cancers by inducing apoptosis of cancer cells and inhibiting cancerous growth. These brassinosteroids were first explored during the 1970s when Mitchell et al. reported promotion in stem elongation and cell division by the treatment of organic extracts of rapeseed (Brassica napus) pollen.^[2] Brassinolide was the first brassinosteroid to be isolated in 1979, when pollen from Brassica napus was shown to promote stem elongation and cell divisions, and the biologically active molecule was isolated.^[3]^[2] The yield of brassinosteroids from 230 kg of Brassica napus pollen was only 10 mg. Since their discovery, over 70 BR compounds have been isolated from plants.^[4]

^ Cite error: The named reference Khripach, VLADIMIR 2000 was invoked but never defined (see the help page).
^ ^a ^b Mitchell JW, Mandava N, Worley JF, Plimmer JR, Smith MV (March 1970). "Brassins—a new family of plant hormones from rape pollen". Nature. 225 (5237): 1065–6. Bibcode:1970Natur.225.1065M. doi:10.1038/2251065a0. PMID 16056912. S2CID 4116426.
^ Grove, Michael D.; Spencer, Gayland F.; Rohwedder, William K.; Mandava, Nagabhushanam; Worley, Joseph F.; Warthen, J. David; Steffens, George L.; Flippen-Anderson, Judith L.; Cook, J. Carter (1979). "Brassinolide, a plant growth-promoting steroid isolated from Brassica napus pollen". Nature. 281 (5728): 216–217. Bibcode:1979Natur.281..216G. doi:10.1038/281216a0. S2CID 4335601.
^ Bajguz, A. (February 2007). "Metabolism of brassinosteroids in plants". Plant Physiology and Biochemistry. 45 (2): 95–107. doi:10.1016/j.plaphy.2007.01.002. PMID 17346983.

[Khripach,_VLADIMIR_2000-1] Cite error: The named reference Khripach, VLADIMIR 2000 was invoked but never defined (see the help page).

[Mitchell-et-al-1970-2] Mitchell JW, Mandava N, Worley JF, Plimmer JR, Smith MV (March 1970). "Brassins—a new family of plant hormones from rape pollen". Nature. 225 (5237): 1065–6. Bibcode:1970Natur.225.1065M. doi:10.1038/2251065a0. PMID 16056912. S2CID 4116426.

[10.1038/281216a0-3] Grove, Michael D.; Spencer, Gayland F.; Rohwedder, William K.; Mandava, Nagabhushanam; Worley, Joseph F.; Warthen, J. David; Steffens, George L.; Flippen-Anderson, Judith L.; Cook, J. Carter (1979). "Brassinolide, a plant growth-promoting steroid isolated from Brassica napus pollen". Nature. 281 (5728): 216–217. Bibcode:1979Natur.281..216G. doi:10.1038/281216a0. S2CID 4335601.

[4] Bajguz, A. (February 2007). "Metabolism of brassinosteroids in plants". Plant Physiology and Biochemistry. 45 (2): 95–107. doi:10.1016/j.plaphy.2007.01.002. PMID 17346983.

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