Brian O'Connell or Bryan O'Connell may refer to:
- Brian O'Connell (advocate) (1930–2011), American author, academic, and public administrator
- Brian O'Connell (musician) (born 1963), American instrumentalist and composer
- Brian O'Connell (hurler) (born 1984), Irish hurler
- Bryan O'Connell, musician in Si Schroeder's band
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