Burkitt lymphoma

Burkitt lymphoma
Other namesBurkitt's tumor, Burkitt's lymphoma, malignant lymphoma Burkitt's type
Burkitt lymphoma, touch prep, Wright stain
SpecialtyHematology and oncology
CausesIdiopathic; HIV; Epstein-Barr Virus; MYC gene translocation
Differential diagnosisDiffuse large B-cell lymphoma, high-grade B cell lymphoma, lymphoblastic leukemia, mantle cell lymphoma (blastoid variant)
TreatmentChemotherapy

Burkitt lymphoma is a cancer of the lymphatic system, particularly B lymphocytes found in the germinal center. It is named after Denis Parsons Burkitt, the Irish surgeon who first described the disease in 1958 while working in equatorial Africa.[1][2] It is a highly aggressive form of cancer which often, but not always, manifests after a person develops acquired immunodeficiency from infection with Epstein-Barr Virus or Human Immunodeficiency Virus (HIV).[3][4]

The overall cure rate for Burkitt lymphoma in developed countries is about 90%. Burkitt lymphoma is uncommon in adults, in whom it has a worse prognosis.[5]

  1. ^ synd/2511 at Who Named It?
  2. ^ Burkitt D (1958). "A sarcoma involving the jaws in African children". The British Journal of Surgery. 46 (197): 218–23. doi:10.1002/bjs.18004619704. PMID 13628987. S2CID 46452308.
  3. ^ Cite error: The named reference Roschewski 2022 NEJM was invoked but never defined (see the help page).
  4. ^ Gonzales, Blanca; Wang, Luojun; Campo, Elias (2021). "Chapter 95: Pathology of Lymphomas". Williams Hematology (10th ed.). New York: McGraw Hill.
  5. ^ Cite error: The named reference pmid22333947 was invoked but never defined (see the help page).

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