Back بوسبيرون Arabic بوسپیرون AZB Bwspiron Welsh Buspiron German Βουσπιρόνη Greek Buspirona Spanish بوسپیرون Persian Buspironi Finnish Buspirone French בוספירון HE

Buspirone

Not to be confused with Bupropion.

Buspirone
Clinical data
Pronunciation/ˈbjuːspɪroʊn/ (BEW-spi-rohn)
Trade namesBuspar, Namanspin
Other namesMJ 9022-1[1]
AHFS/Drugs.comMonograph
MedlinePlusa688005
License data
Pregnancy
category
  • AU: B1
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability3.9%[3]
Protein binding86–95%[4]
MetabolismLiver (via CYP3A4)[8][9]
Metabolites5-OH-Buspirone; 6-OH-Buspirone; 8-OH-Buspirone; 1-PPTooltip 1-(2-pyrimidinyl)piperazine[5][6][7]
Elimination half-life2.5 hours[8]
ExcretionUrine: 29–63%[4]
Feces: 18–38%[4]
Identifiers
  • 8-{4-[4-(Pyrimidin-2-yl)piperazin-1-yl]butyl}-8-azaspiro[4.5]decane-7,9-dione
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.048.232 Edit this at Wikidata
Chemical and physical data
FormulaC21H31N5O2
Molar mass385.512 g·mol−1
3D model (JSmol)
  • O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(c2ncccn2)CC1
  • InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2 checkY
  • Key:QWCRAEMEVRGPNT-UHFFFAOYSA-N checkY
  (verify)

Buspirone, sold under the brand name Buspar, among others, is an anxiolytic, a medication primarily used to treat anxiety disorders, particularly generalized anxiety disorder.[10][11] It is a serotonin 5-HT1A receptor agonist, increasing action at serotonin receptors in the brain.[3] It is taken orally, and takes two to six weeks to be fully effective.[10][11]

Common side effects of buspirone include nausea, headaches, dizziness, and difficulty concentrating.[10][12] Serious side effects may include movement disorders, serotonin syndrome, and seizures.[12] Its use in pregnancy appears to be safe but has not been well studied, and use during breastfeeding has not been well studied.[12][13]

Buspirone was developed in 1968 and approved for medical use in the United States in 1986.[10][11] It is available as a generic medication.[12] In 2021, it was the 53rd most-commonly prescribed medication in the United States, with more than 12 million prescriptions.[14][15]

  1. ^ Cite error: The named reference Elks2014 was invoked but never defined (see the help page).
  2. ^ Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.
  3. ^ a b Loane C, Politis M (June 2012). "Buspirone: what is it all about?". Brain Research. 1461: 111–118. doi:10.1016/j.brainres.2012.04.032. PMID 22608068. S2CID 11734819.
  4. ^ a b c "buspirone (Rx) - BuSpar, Buspirex, more." Medscape Reference. WebMD. Retrieved 14 November 2013.
  5. ^ Cite error: The named reference pmid3515929 was invoked but never defined (see the help page).
  6. ^ Cite error: The named reference SchatzbergNemeroff2009 was invoked but never defined (see the help page).
  7. ^ Cite error: The named reference pmid17494642 was invoked but never defined (see the help page).
  8. ^ a b Mahmood I, Sahajwalla C (April 1999). "Clinical pharmacokinetics and pharmacodynamics of buspirone, an anxiolytic drug". Clinical Pharmacokinetics. 36 (4): 277–287. doi:10.2165/00003088-199936040-00003. PMID 10320950. S2CID 1102318.
  9. ^ Zhu M, Zhao W, Jimenez H, Zhang D, Yeola S, Dai R, et al. (April 2005). "Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes". Drug Metabolism and Disposition. 33 (4): 500–507. doi:10.1124/dmd.104.000836. PMID 15640381. S2CID 10142905.
  10. ^ a b c d "Buspirone Hydrochloride Monograph for Professionals". Drugs.com.
  11. ^ a b c Wilson TK, Tripp J (January 2018). "Buspirone". StatPearls. PMID 30285372.
  12. ^ a b c d British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 338. ISBN 9780857113382.
  13. ^ "Buspirone Pregnancy and Breastfeeding Warnings". Drugs.com.
  14. ^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
  15. ^ "Buspirone - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.

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