CCR5

CCR5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L87, 2RLL, 2RRS, 2MZX, 4MBS
Identifiers
Aliases	CCR5, CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22, C-C motif chemokine receptor 5 (gene/pseudogene), C-C motif chemokine receptor 5
External IDs	OMIM: 601373; MGI: 107182; HomoloGene: 37325; GeneCards: CCR5; OMA:CCR5 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	46,376,206 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	123,947,736 bp
RNA expression pattern
	Top expressed in
	epithelium of nasopharynx; ; parietal pleura; ; visceral pleura; ; palpebral conjunctiva; ; granulocyte; ; germinal epithelium; ; mucosa of urinary bladder; ; appendix; ; superficial temporal artery; ; jejunal mucosa;
	Top expressed in
	lumbar subsegment of spinal cord; ; morula; ; lumbar spinal ganglion; ; blood; ; embryo; ; lymph node; ; mesenteric lymph nodes; ; submandibular gland; ; blastocyst; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; coreceptor activity; chemokine (C-C motif) ligand 5 binding; virus receptor activity; signal transducer activity; protein binding; chemokine receptor activity; C-C chemokine receptor activity; actin binding; phosphatidylinositol phospholipase C activity; C-C chemokine binding; chemokine binding;
Cellular component	cytoplasm; integral component of membrane; endosome; membrane; plasma membrane; integral component of plasma membrane; external side of plasma membrane; cell surface;
Biological process	G protein-coupled receptor signaling pathway; signaling; response to cholesterol; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; positive regulation of cytosolic calcium ion concentration; cell-cell signaling; dendritic cell chemotaxis; MAPK cascade; chemotaxis; cellular defense response; cell surface receptor signaling pathway; immune response; inflammatory response; cellular response to lipopolysaccharide; calcium ion transport; calcium-mediated signaling; signal transduction; fusion of virus membrane with host plasma membrane; chemokine-mediated signaling pathway; viral process; defense response; negative regulation of macrophage apoptotic process; cytokine-mediated signaling pathway; cell chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	1234
	12774
	ENSG00000160791
	ENSMUSG00000079227
	P51681
	P51682
	NM_001100168; NM_000579; NM_001394783
	NM_009917
	NP_000570; NP_001093638
	NP_034047
	Wikidata
View/Edit Human	View/Edit Mouse

C-C chemokine receptor type 5, also known as CCR5 or CD195, is a protein on the surface of white blood cells that is involved in the immune system as it acts as a receptor for chemokines.^[5]

In humans, the CCR5 gene that encodes the CCR5 protein is located on the short (p) arm at position 21 on chromosome 3. Certain populations have inherited the Delta 32 mutation, resulting in the genetic deletion of a portion of the CCR5 gene. Homozygous carriers of this mutation are resistant to infection by macrophage-tropic (M-tropic) strains of HIV-1.^[6]^[7]^[8]^[9]^[10]^[11]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160791 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000079227 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jiao X, Nawab O, Patel T, Kossenkov AV, Halama N, Jaeger D, et al. (October 2019). "Recent Advances Targeting CCR5 for Cancer and Its Role in Immuno-Oncology". Cancer Research. 79 (19): 4801–4807. doi:10.1158/0008-5472.CAN-19-1167. PMC 6810651. PMID 31292161.
^ de Silva E, Stumpf MP (December 2004). "HIV and the CCR5-Delta32 resistance allele". FEMS Microbiology Letters. 241 (1): 1–12. doi:10.1016/j.femsle.2004.09.040. PMID 15556703.
^ Hütter G, Nowak D, Mossner M, Ganepola S, Müssig A, Allers K, et al. (February 2009). "Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation". The New England Journal of Medicine. 360 (7): 692–698. doi:10.1056/NEJMoa0802905. PMID 19213682.
^ Allers K, Hütter G, Hofmann J, Loddenkemper C, Rieger K, Thiel E, et al. (March 2011). "Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation". Blood. 117 (10): 2791–2799. doi:10.1182/blood-2010-09-309591. PMID 21148083.
^ Zhen A, Kitchen S (December 2013). "Stem-cell-based gene therapy for HIV infection". Viruses. 6 (1): 1–12. doi:10.3390/v6010001. PMC 3917429. PMID 24368413.
^ Kay MA, Walker BD (March 2014). "Engineering cellular resistance to HIV". The New England Journal of Medicine. 370 (10): 968–969. doi:10.1056/NEJMe1400593. PMID 24597871.
^ Tebas P, Stein D, Tang WW, Frank I, Wang SQ, Lee G, et al. (March 2014). "Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV". The New England Journal of Medicine. 370 (10): 901–910. doi:10.1056/NEJMoa1300662. PMC 4084652. PMID 24597865.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000160791 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000079227 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid31292161-5] Jiao X, Nawab O, Patel T, Kossenkov AV, Halama N, Jaeger D, et al. (October 2019). "Recent Advances Targeting CCR5 for Cancer and Its Role in Immuno-Oncology". Cancer Research. 79 (19): 4801–4807. doi:10.1158/0008-5472.CAN-19-1167. PMC 6810651. PMID 31292161.

[pmid15556703-6] Silva E, Stumpf MP (December 2004). "HIV and the CCR5-Delta32 resistance allele". FEMS Microbiology Letters. 241 (1): 1–12. doi:10.1016/j.femsle.2004.09.040. PMID 15556703.

[pmid19213682-7] Hütter G, Nowak D, Mossner M, Ganepola S, Müssig A, Allers K, et al. (February 2009). "Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation". The New England Journal of Medicine. 360 (7): 692–698. doi:10.1056/NEJMoa0802905. PMID 19213682.

[pmid21148083-8] Allers K, Hütter G, Hofmann J, Loddenkemper C, Rieger K, Thiel E, et al. (March 2011). "Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation". Blood. 117 (10): 2791–2799. doi:10.1182/blood-2010-09-309591. PMID 21148083.

[pmid24368413-9] Zhen A, Kitchen S (December 2013). "Stem-cell-based gene therapy for HIV infection". Viruses. 6 (1): 1–12. doi:10.3390/v6010001. PMC 3917429. PMID 24368413.

[pmid24597871-10] Kay MA, Walker BD (March 2014). "Engineering cellular resistance to HIV". The New England Journal of Medicine. 370 (10): 968–969. doi:10.1056/NEJMe1400593. PMID 24597871.

[pmid24597865-11] Tebas P, Stein D, Tang WW, Frank I, Wang SQ, Lee G, et al. (March 2014). "Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV". The New England Journal of Medicine. 370 (10): 901–910. doi:10.1056/NEJMoa1300662. PMC 4084652. PMID 24597865.

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