CD20

MS4A1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3PP4, 2OSL, 3BKY
Identifiers
Aliases	MS4A1, B1, Bp35, CD20, CVID5, LEU-16, MS4A2, S7, membrane spanning 4-domains A1, FMC7
External IDs	OMIM: 112210; MGI: 88321; HomoloGene: 7259; GeneCards: MS4A1; OMA:MS4A1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	60,470,752 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	11,243,605 bp
RNA expression pattern
	Top expressed in
	epithelium of nasopharynx; ; spleen; ; lymph node; ; mucosa of ileum; ; appendix; ; granulocyte; ; blood; ; tonsil; ; bone marrow; ; superficial temporal artery;
	Top expressed in
	mesenteric lymph nodes; ; spleen; ; blood; ; oocyte; ; primary oocyte; ; submandibular gland; ; tibiofemoral joint; ; secondary oocyte; ; zygote; ; Ileal epithelium;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	epidermal growth factor receptor binding; protein binding; MHC class II protein complex binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; extracellular exosome; membrane; external side of plasma membrane; extracellular space; nucleus;
Biological process	B cell activation; B cell proliferation; humoral immune response; response to bacterium;
	Sources:Amigo / QuickGO
Orthologs
	931
	12482
	ENSG00000156738
	ENSMUSG00000024673
	P11836
	P19437
	NM_152866; NM_021950; NM_152867
	NM_007641
	NP_068769; NP_690605; NP_690606
	NP_031667
	Wikidata
View/Edit Human	View/Edit Mouse

B-lymphocyte antigen CD20 or CD20 is B lymphocyte cell-surface molecule.

It is a 33-37 kDa non-glycosylated protein. CD20 is expressed on the surface of B-cells from the pre-B phase, the expression is lost in terminally differentiated plasma cells.^[5]^[6]

CD20 is used as a therapeutical target of B-cell malignancies and autoimmune diseases.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000156738 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024673 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hardy R (2008). "Chapter 7: B Lymphocyte Development and Biology". In Paul W (ed.). Fundamental Immunology (Book) (6th ed.). Philadelphia: Lippincott Williams & Wilkins. pp. 237–269. ISBN 978-0-7817-6519-0.
^ ^a ^b Pavlasova G, Mraz M (June 2020). "The regulation and function of CD20: an "enigma" of B-cell biology and targeted therapy". Haematologica. 105 (6): 1494–1506. doi:10.3324/haematol.2019.243543. PMC 7271567. PMID 32482755.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000156738 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024673 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Paul0807-5] Hardy R (2008). "Chapter 7: B Lymphocyte Development and Biology". In Paul W (ed.). Fundamental Immunology (Book) (6th ed.). Philadelphia: Lippincott Williams & Wilkins. pp. 237–269. ISBN 978-0-7817-6519-0.

[Pavlasova_2020-6] Pavlasova G, Mraz M (June 2020). "The regulation and function of CD20: an "enigma" of B-cell biology and targeted therapy". Haematologica. 105 (6): 1494–1506. doi:10.3324/haematol.2019.243543. PMC 7271567. PMID 32482755.

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