| Cytochrome P450 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Mechanism of CYP450 enzymatic catalysis | |||||||||
| Identifiers | |||||||||
| Symbol | p450 | ||||||||
| Pfam | PF00067 | ||||||||
| InterPro | IPR001128 | ||||||||
| PROSITE | PDOC00081 | ||||||||
| SCOP2 | 2cpp / SCOPe / SUPFAM | ||||||||
| OPM superfamily | 39 | ||||||||
| OPM protein | 2bdm | ||||||||
| CDD | cd00302 | ||||||||
| Membranome | 265 | ||||||||
| |||||||||
Cytochrome P450, family 3, subfamily A, also known as CYP3A, is a human gene locus.[1][2] A homologous locus is found in mice.[3] These genes encode monooxygenases which catalyze many reactions involved in the synthesis of cholesterol, steroids and other lipids as well as drug metabolism.
The CYP3A locus includes all the known members of the 3A subfamily of the cytochrome P450 superfamily of genes. The CYP3A cluster consists of four genes:
The region also contains four pseudogenes:
as well as several extra exons which may or may not be included in transcripts produced from this region. Previously another CYP3A member, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4.[1]
- ^ a b "Entrez Gene: CYP3A cytochrome P450, family 3, subfamily A".
- ^ Gellner K, Eiselt R, Hustert E, Arnold H, Koch I, Haberl M, et al. (March 2001). "Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene". Pharmacogenetics. 11 (2): 111–121. doi:10.1097/00008571-200103000-00002. PMID 11266076.
- ^ Zaphiropoulos PG (June 2003). "A map of the mouse Cyp3a locus". DNA Sequence : The Journal of DNA Sequencing and Mapping. 14 (3): 155–162. doi:10.1080/1042517031000089478. PMID 14509827. S2CID 21317627.
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