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Calmodulin

Calmodulin
3D structure of Ca2+-bound calmodulin (PDB: 1OSA​)
Identifiers
SymbolCaM
PDB1OSA
UniProtP62158
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StructuresSwiss-model
DomainsInterPro
The helix–loop–helix structure of the calcium-binding EF hand motif

Calmodulin (CaM) (an abbreviation for calcium-modulated protein) is a multifunctional intermediate calcium-binding messenger protein expressed in all eukaryotic cells.[1] It is an intracellular target of the secondary messenger Ca2+, and the binding of Ca2+ is required for the activation of calmodulin. Once bound to Ca2+, calmodulin acts as part of a calcium signal transduction pathway by modifying its interactions with various target proteins such as kinases or phosphatases.[2][3][4]

  1. ^ Stevens FC (August 1983). "Calmodulin: an introduction". Canadian Journal of Biochemistry and Cell Biology. 61 (8): 906–10. doi:10.1139/o83-115. PMID 6313166.
  2. ^ Chin D, Means AR (August 2000). "Calmodulin: a prototypical calcium sensor". Trends in Cell Biology. 10 (8): 322–8. doi:10.1016/S0962-8924(00)01800-6. PMID 10884684.
  3. ^ Purves D, Augustine G, Fitzpatrick D, Hall W, LaMantia AS, White L (2012). Neuroscience. Massachusetts: Sinauer Associates. pp. 95, 147, 148. ISBN 9780878936953.
  4. ^ "CALM1 – Calmodulin – Homo sapiens (Human) – CALM1 gene & protein". www.uniprot.org. Retrieved 2016-02-23.

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