Catalase | |||||||||
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Identifiers | |||||||||
Symbol | Catalase | ||||||||
Pfam | PF00199 | ||||||||
InterPro | IPR011614 | ||||||||
PROSITE | PDOC00395 | ||||||||
SCOP2 | 7cat / SCOPe / SUPFAM | ||||||||
OPM superfamily | 370 | ||||||||
OPM protein | 3e4w | ||||||||
CDD | cd00328 | ||||||||
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Aliases | CAT, catalase | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 115500; MGI: 88271; HomoloGene: 55514; GeneCards: CAT; OMA:CAT - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Catalase is a common enzyme found in nearly all living organisms exposed to oxygen (such as bacteria, plants, and animals) which catalyzes the decomposition of hydrogen peroxide to water and oxygen.[5] It is a very important enzyme in protecting the cell from oxidative damage by reactive oxygen species (ROS). Catalase has one of the highest turnover numbers of all enzymes; one catalase molecule can convert millions of hydrogen peroxide molecules to water and oxygen each second.[6]
Catalase is a tetramer of four polypeptide chains, each over 500 amino acids long.[7] It contains four iron-containing heme groups that allow the enzyme to react with hydrogen peroxide. The optimum pH for human catalase is approximately 7,[8] and has a fairly broad maximum: the rate of reaction does not change appreciably between pH 6.8 and 7.5.[9] The pH optimum for other catalases varies between 4 and 11 depending on the species.[10] The optimum temperature also varies by species.[11]
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